Korean J Gastroenterol.
2000 Apr;35(4):492-500.
Immunohistochemical Study of Solid-Pseudopapillary Tumor of the Pancreas
Abstract
- BACKGROUND/AIMS
The solid-pseudopapillary tumor of the pancreas occurs
predominantly in young women, and most of them seem to be benign. The histogenesis
of this tumor remains unclear. In this study, we reviewed the clinicopathologic
findings and immunohistochemical staining pattern of eleven cases of solid-pseudopapillary
tumor of the pancreas. METHODS: Eleven cases of solid- pseudopapillary tumor of
the pancreas were reviewed and immunohistochemistry with 12 antibodies was performed.
Two cases were examined by electron microscopy. RESULTS: All of the cases were female
with a mean age of 27.9 years. Grossly, tumors were well demarcated multinodular mass
with solid, cystic and hemorrhagic pattern and the mean diameter was 7.7 cm. Histologic
examination showed that uniform cells formed solid sheets, and loss of cohesion produced
pseudopapillae. Immunohistochemically, the all cases were reactive for vimentin and
neuron specific enolase. Three cases expressed progesteron receptor, two cases expressed
cytokeratin, and one case expressed alpha-1 antitrypsin. None of the cases showed
expression of estrogen receptor, chromogranin, synaptophysin, lipase, epithelial
membrane antigen, carcinoembryonic antigen or p53 protein. CONCLUSIONS:
The solid-pseudopapillary tumor of the pancreas is possibly originated from pluripotent
stem cells, but lacks definite evidences of endocrine or exocrine differentiation.