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Theracurmin Ameliorates Cognitive Dysfunctions in 5XFAD Mice by Improving Synaptic Function and Mitigating Oxidative Stress

Kim J, Kim J, Huang Z, Goo N, Bae HJ, Jeong Y, Park HJ, Cai M, Cho K, Jung SY, Bae SK, Ryu JH

As the elderly population is increasing, Alzheimer's disease (AD) has become a global issue and many clinical trials have been conducted to evaluate treatments for AD. As these clinical trials...
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Epiretinal Proliferation Associated with Lamellar Hole or Macular Hole: Origin and Surgical Prognosis

Yang YS, Lee JS, Son G, Sohn J

PURPOSE: To determine the origin of epiretinal proliferation (EP), a condition that is occasionally observed in lamellar hole and macular hole cases, and EP outcomes after vitrectomy. METHODS: This is a...
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Prognostic Threshold of Neuroendocrine Differentiation in Gastric Carcinoma: a Clinicopathological Study of 945 Cases

Zou Y, Chen L, Wang X, Chen Y, Hu L, Zeng S, Wang P, Li G, Huang M, Wang L, He S, Li S, Jian L, Zhang S

PURPOSE: The significance of neuroendocrine differentiation (NED) in gastric carcinoma (GC) is controversial, leading to ambiguous concepts in traditional classifications. This study aimed to determine the prognostic threshold of meaningful...
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Pathologic differential diagnosis of metastatic carcinoma in the liver

Park JH, Kim JH

The liver is one of the most common sites to which malignancies preferentially metastasize. Although a substantial number of liver malignancies are primary tumors, including hepatocellular carcinoma and intrahepatic cholangiocarcinoma,...
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Long-term postresection prognosis of primary neuroendocrine tumors of the liver

Jung J, Hwang S, Hong SM, Kim KH, Ahn CS, Moon DB, Ha TY, Song GW, Park YH

PURPOSE: Primary hepatic neuroendocrine tumor (PHNET) is a very rare neoplasm, requiring strict exclusion of metastasis from possible extrahepatic primary sites for its diagnosis. METHODS: We reviewed our clinical experience of...
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Poorly Differentiated Neuroendocrine Carcinoma of the Eyelid

Cho K, Kim JH, Lee DC, Suh YL, Woo KI, Kim YD

PURPOSE: To report a case of poorly differentiated neuroendocrine carcinoma of the eyelid. CASE SUMMARY: A 70-year-old male presented with a 5-month history of a right upper eyelid mass. The mass...
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Large Cell Neuroendocrine Carcinoma of the Colon With Carcinomatosis Peritonei

Kim JJ, Park SS, Lee TG, Lee HC, Lee SJ

Colorectal large-cell neuroendocrine carcinomas (NECs) are extremely rare and have very poor prognosis compared to adenocarcinomas. A 74-year-old man presented with abdominal pain, diarrhea and hematochezia. The histopathologic report of...
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Pancreatic Neuroendocrine Tumor Presenting as Acute Pancreatitis

Kim M, Park JM, Lee SJ, Kang CD, Kang M, Kim JH, Lee S, Cho SW

We report a case of acute pancreatitis secondary to pancreatic neuroendocrine tumor. A 46-year old man presented with upper abdominal pain. The serum amylase and lipase were elevated. Abdominal computed...
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Large Cell Neuroendocrine Carcinoma of the Extrahepatic Bile Duct

Park JY, Jeon TJ

Primary neuroendocrine tumors originating from the extrahepatic bile duct are rare. Among these tumors, large cell neuroendocrine carcinomas (NECs) are extremely rare. A 59-year-old man was admitted to Sanggye Paik...
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An Intrarenal Adrenocortical Carcinoma Arising in an Adrenal Rest

Lee JH, Choi YD, Cho NH

We describe a case of a 61-year-old Korean man who was diagnosed with renal cell carcinoma that was discovered on abdominopelvic computed tomography obtained after the patient complained of back...
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Differential Expression of Ca²⁺-buffering Protein Calretinin in Cochlear Afferent Fibers: A Possible Link to Vulnerability to Traumatic Noise

Sharma K, Seo YW, Yi E

The synaptic contacts of cochlear afferent fibers (CAFs) with inner hair cells (IHCs) are spatially segregated according to their firing properties. CAFs also exhibit spatially segregated vulnerabilities to noise. The...
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Endoscopic Papillectomy for Synchronous Major and Minor Duodenal Papilla Neuroendocrine Tumors

Seo YK, Choi JS

Neuroendocrine tumor (NET) of the major duodenal papilla is a rare occurrence. However, that of the minor duodenal papilla is even rarer. To date, only a few cases have been...
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Valproic Acid Induces Telomerase Reverse Transcriptase Expression during Cortical Development

Kim KC, Choi CS, Gonzales E, Mabunga DF, Lee SH, Jeon SJ, Hwangbo R, Hong M, Ryu JH, Han SH, Bahn GH, Shin CY

The valproic acid (VPA)-induced animal model is one of the most widely utilized environmental risk factor models of autism. Autism spectrum disorder (ASD) remains an insurmountable challenge among neurodevelopmental disorders...
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Epithelioid Malignant Intracerebral Nerve Sheath Tumor: A Case Report and a Comparison with Conventional Type

Son SM, Park YS, Lee OJ

Malignant peripheral nerve sheath tumors (MPNSTs) are defined as malignant tumors arising from peripheral nerves or differentiating along the line of the elements of the nerve sheath. MPNSTs that originate...
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A Concurrence of Adenocarcinoma with Micropapillary Features and Composite Glandular-Endocrine Cell Carcinoma in the Stomach

Kim JH, Eom DW, Park CS, Kwak JY, Park EH, Kwak JH, Jang HJ, Choi KM, Han MS

We report a unique case of synchronous double primary gastric cancer consisting of adenocarcinoma components with micropapillary features and composite glandular-endocrine cell carcinoma components. The patient was a 53-year-old man...
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A Case of Endoscopically Complete Remission of Esophageal Neuroendocrine Tumors by Concurrent Chemoradiation Therapy

Kim MH, Jeong HY, Seong JK, Moon HS, Kang SH, Kim DK

Neuroendocrine tumors (NETs) of the esophagus are extremely rare, aggressive and have a poor prognosis. Combined therapy using chemotherapy, radiotherapy and/or surgery appear effective. Here, we present a patient with...
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Central Neurocytoma: A Review of Clinical Management and Histopathologic Features

Lee SJ, Bui TT, Chen CH, Lagman C, Chung LK, Sidhu S, Seo DJ, Yong WH, Siegal TL, Kim M, Yang I

Central neurocytoma (CN) is a rare, benign brain tumor often located in the lateral ventricles. CN may cause obstructive hydrocephalus and manifest as signs of increased intracranial pressure. The goal...
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A Calcitonin-Negative Neuroendocrine Tumor Derived from Follicular Lesions of the Thyroid

Kim GY, Park CY, Cho CH, Park JS, Jung ED, Jeon EJ

Neuroendocrine lesions of the thyroid are rare. The most common types are medullary thyroid carcinomas (MTCs) and C-cell hyperplasia. MTCs originate from thyroid parafollicular cells that secrete calcitonin which serves...
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A Case of Primary Cutaneous CD30+ Anaplastic Large Cell Lymphoma, Small Cell Variant

Min J, Kim HS, Hwang SH, Lee HJ, Nam JH, Jung HJ, Park JH, Lee GY, Kim WS

  • KMID: 2301509
  • Korean J Dermatol.
  • 2015 May;53(4):304-309.
Primary cutaneous anaplastic large cell lymphoma (PCALCL) is a rare cutaneous T-cell lymphoma. Most cases are composed of large anaplastic cells. However, it presents a wide spectrum of histologic patterns....
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Primary Neuroendocrine Carcinoma of the Breast with Clinical Features of Inflammatory Breast Carcinoma: A Case Report and Literature Review

Lee DH, Park AY, Seo BK, Kim YS, Lee KY, Cha SH

Primary neuroendocrine carcinoma of the breast (NECB) is a very rare type of invasive breast carcinoma. Most NECBs appear on breast imaging as solid masses of varied shapes and margins,...
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