Korean J Gastroenterol.  2018 Oct;72(4):217-221. 10.4166/kjg.2018.72.4.217.

Endoscopic Papillectomy for Synchronous Major and Minor Duodenal Papilla Neuroendocrine Tumors

  • 1Division of Gastroenterology, Department of Internal Medicine, Seoul You Hospital, Division of Gastroenterology, Busan, Korea.
  • 2Department of Internal Medicine, Busan Paik hospital, Inje University College of Medicine, Busan, Korea. jschoi@paik.ac.kr


Neuroendocrine tumor (NET) of the major duodenal papilla is a rare occurrence. However, that of the minor duodenal papilla is even rarer. To date, only a few cases have been reported. Herein, we present a rare case of NETs detected at the major and minor duodenal papilla synchronously, which were successfully treated with endoscopic papillectomy without procedure-related complication. To the best of our knowledge, this is the first report of this kind in the world. Photomicrograph of the biopsy specimen stained immunohistochemically for synaptophysin showed a positive reaction of tumor cells. All resection margins were negative. Further experience with more cases will be needed to establish the exact indication of endoscopic papillectomy for duodenal papillary NETs.


Neuroendocrine tumors; Major duodenal papilla; Minor duodenal papilla
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