Korean J Anesthesiol.  1993 Apr;26(2):314-320. 10.4097/kjae.1993.26.2.314.

Cardiorespiratory Changes with Benzodiazepine Derivatives during Spinal Anesthesia in Elderly Patients

• Kim MC
• Yu BS
• Cho NS
• Lim GJ
• Chung CD
• Kim YI

• KMID: 2239261
• DOI: http://doi.org/10.4097/kjae.1993.26.2.314

Abstract

Midazolam, a water soluble benzodiazepine, was compared with diazepam as the changes of eardiopulmonary function during sedation under the spinal anesthesia in elderly patients. The results were as follows; I) Cardiovascular effect. At the conclusion after diazepam 0.05 mg/kg(Group D) or midazolam 0.02 mg/kg(Group M) injection, systolic, diastolic pressure and heart rate were significantly decreased(P<0.05) in the both group from 3 min to 30 min, but maintained within normal range. However, it is not significant difference that each group. 2) Respiratory effect. SaO decreased significantly at 3 min. in M-group after midazolam injection but there was not significant difference from change in D-group. Respiratory rate, pH and PaCO2 were not significantly changed between D-group and M-group. However, PaO2 was significantly decreased(p<0.05) within normal range at 3 min. in M-group after midazolam IV and significant difference between both groups. From the above results, We have concluded that IV administration of small dose of diazepam or midaaolam during spinal anesthesia had a little changed in cardiopulmonary function. However, sedative effect was efficient.

Keyword

Sedation; Spinal anesthesia; Diazepam; Midazolam; Cardiopulmonary function

MeSH Terms

Aged*
Anesthesia, Spinal*
Benzodiazepines*
Blood Pressure
Diazepam
Heart Rate
Humans
Hydrogen-Ion Concentration
Hypnotics and Sedatives
Midazolam
Reference Values
Respiratory Rate
Benzodiazepines
Diazepam
Hypnotics and Sedatives
Midazolam