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Risk of Dementia in Long-Term Benzodiazepine Users: Evidence from a Meta-Analysis of Observational Studies

He Q, Chen X, Wu T, Li L, Fei X

BACKGROUND AND PURPOSE: There is conflicting evidence in the literature on the association between benzodiazepines (BDZs) and the risk of dementia. This meta-analysis aimed to determine the relationship between the...
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Assessment of Switching to Suvorexant versus the Use of Add-on Suvorexant in Combination with Benzodiazepine Receptor Agonists in Insomnia Patients: A Retrospective Study

Hatano M, Kamei H, Inagaki R, Matsuzaki , Hanya M, Yamada S, Iwata N

OBJECTIVE: Suvorexant is a novel hypnotic drug that does not interact with the conventional γ-aminobutyric acid (GABA)-A receptor. We investigated the method by which suvorexant was introduced in insomnia patients...
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Benzodiazepine Use among Patients with Schizophrenia in Korea: Analysis of Database of Health Insurance Review Agency

Choi S, Lee SU, Hwang TY

OBJECTIVE: This study was designed to examine the pattern of benzodiazepine use in a representative sample of patients with schizophrenia in Korea. METHOD: Data generated by the Health Insurance Review Agency...
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Risk Factors for Aspiration Pneumonia in Acute Benzodiazepine Overdose

Chung WS, Cha KM, Kim HM, Jeong WJ, So BH

  • KMID: 2328236
  • J Korean Soc Clin Toxicol.
  • 2016 Jun;14(1):26-32.
PURPOSE: Aspiration pneumonia is an important complication of drug intoxication with decreased mental status. The purpose of the study is to investigate the risk factors of aspiration pneumonia in the...
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Clinical Analysis of Flumazenil Administration in the Single Emergency Department for Unconscious Patients, Suspected Benzodiazepine Overdose

Kim HJ, Kim YH, Lee JH, Hwang SY, Cho KW, Kang MJ, Lee DW, Lee KY, Lee NK

PURPOSE: Flumazenil is an effective benzodiazepine antagonist. However, serious adverse effects, including seizures, cardiac arrhythmias, and even death, have been reported in patients treated with flumazenil. These adverse effects are...
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Quantitative EEG Characteristics of Periodic Lateralized Epileptiform Discharges according to Benzodiazepine Responsiveness

Kim YS, Jung KY, Kim JM, Kim D

BACKGROUND: Periodic lateralized epileptiform discharges (PLEDs) are associated with altered consciousness in 75% of patients. Major controversy about PLEDs is whether they are ictal or interictal phenomenon. Diagnosis of non-convulsive...
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A Case of Pulmonary Thromboembolism Complicating Acute Overdose of Benzodiazepines

Choi JY, Jeong J

  • KMID: 2333825
  • J Korean Soc Emerg Med.
  • 2014 Apr;25(2):199-201.
Acute pulmonary thromboembolism (PTE) is a major medical problem in many hospitalized patients with medical and surgical conditions, and venous thromboembolism is responsible for up to 15% of all in-hospital...
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Efficacy of Benzodiazepines to Laryngopharyngeal Reflux: A Double-Blind, Randomized Controlled Study

Park KH, Koo BJ, Park JJ, Kim SK, Choi SM, Kwon SU, Yoon SW

  • KMID: 2276497
  • Korean J Otolaryngol-Head Neck Surg.
  • 2005 Oct;48(10):1267-1270.
BACKGROUND AND OBJECTIVES: Anti-anxiety drugs such as benzodiazepines are often given to globus patients in practice, based on the notion that globus is a kind of somatization disorder. However, many...
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Superfluous Use of Benzodiazepines in Patients with Major Depression Treated with Mirtazapine

Suh HS, Kim CH, Koo MS, Lee HS

  • KMID: 2286876
  • Korean J Psychopharmacol.
  • 2004 Mar;15(1):58-65.
OBJECTIVE: The purpose of this study is to evaluate the usefulness of administration of benzodiazepines in patients with major depression being treated with the antidepressant mirtazapine. METHODS: The subjects of...
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Clinical Use of Flumazenil in the Emergency Department for Suspected Benzodiazepine Overdose

Lee MJ, Kim HJ, So BH, Lee WJ, Kim SK

  • KMID: 1998725
  • J Korean Soc Emerg Med.
  • 2003 Dec;14(5):529-535.
PURPOSE: Flumazenil is the specific benzodiazepine (BZP)antagonist indicated for the reversal of the sedative effect of BZP. We evaluated the safety and the effectiveness of using flumazenil to treat suspected...
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Coadministration of Nefazodone and Benzodiazepine in the Early Phase of Treatment of Depression

Shin IS, Yoon JS, Jeong HJ, Lee JG, Lee HY

  • KMID: 2286920
  • Korean J Psychopharmacol.
  • 2001 Sep;12(3):222-232.
OBJECTIVE: The purpose of this study was to examine the efficacy and safety of coadministration of nefazodone (NEF) and benzodiazepine (BZD) in the clinical setting, particularly during the initial period...
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Glial Peripheral Benzodiazepine Receptor Mediates the Relief of Acute Stress-Induced Anxiety in Rats

Kim YU, Park HB, Lee JB, Kim JS, Cheung SD, Ha JH, Song CJ

  • KMID: 2340325
  • J Korean Neuropsychiatr Assoc.
  • 1999 May;38(3):647-655.
OBJECTIVES: Peripheral benzodiazepine receptor has been suggested to be associated with the relief of anxiety response induced by stresses. This study was designed to observe the anxiolytic activity of...
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Effects of Repeated Immobilization Stress on the Renal Peripheral Benzodiazepine Receptor in Rats

Park YH, Moon HK, Shin SM, Lee EJ, Lee ES, Ha JH

  • KMID: 1543943
  • J Korean Soc Pediatr Nephrol.
  • 1999 May;3(1):20-26.
Primary small cell carcinoma of the salivary gland is a rare neoplasm that accounts for approximately 1.8% of all primary major salivary gland malignancies. Because of its rarity, it is...
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Synthesis and Biodistribution of Flumazenil Derivative [F-18](3-(2-Fluoro) flumazenil for Imaging Benzodiazepine Receptor

Hong SH, Jeong JM, Chang YS, Lee DS, Chung JK, Cho JH, Lee SJ, Kang SS, Lee MC

  • KMID: 2038081
  • Korean J Nucl Med.
  • 1999 Dec;33(6):527-536.
PURPOSE: Radiotracers that bind to the central benzodiazepine receptor are useful for the investigation of various neurological and psychiatric diseases. [C-11]Flumazenil, a benzodiazepine antagonist, is the most widely used radioligand...
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Involvement of peripheral benzodiazepine receptor on contractility of canine trachealis muscle

Rhyu HY, Choi HC, Choi EM, Sohn UD, Lee KY, Kim WJ, Ha JH

  • KMID: 2285195
  • Korean J Physiol Pharmacol.
  • 1997 Dec;1(6):769-774.
Non-neuronal high affinity binding sites for benzodiazepines have been found in many peripheral tissues including cardiac muscle and vascular smooth muscle, and have been designated as 'peripheral benzodiazepine receptor'. Benzodiazepines have been shown...
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Changes of renal peripheral benzodiazepine receptor in the stress/anxiety response

Ha JH, Lee KH, Cheung SD, Park HB, Lee MG, Choi HC, Sohn UD, Lee KY, Kim WJ

  • KMID: 1554762
  • Korean J Physiol Pharmacol.
  • 1997 Oct;1(5):523-528.
Peripheral benzodiazepine receptor(PBR) has been identified in various peripheral tissues including kidney. The physiological and pharmacological functions of PBR are still uncertain, although it has been suggested that these are associated with the...
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Cardiorespiratory Changes with Benzodiazepine Derivatives during Spinal Anesthesia in Elderly Patients

Kim MC, Yu BS, Cho NS, Lim GJ, Chung CD, Kim YI

Midazolam, a water soluble benzodiazepine, was compared with diazepam as the changes of eardiopulmonary function during sedation under the spinal anesthesia in elderly patients. The results were as follows; I)...
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Use of and dependence on benzodiazepines

Min SK

  • KMID: 1691897
  • J Korean Neuropsychiatr Assoc.
  • 1991 May;30(3):451-461.
No abstract available.
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GABA, benzodiazepine receptors and their functions

Chung YC, Han GS

  • KMID: 1691895
  • J Korean Neuropsychiatr Assoc.
  • 1991 May;30(3):431-450.
No abstract available.
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Evaluation of a New Benzodiazepine, Flunitrazepam (Ro 5-4200) as an Anesthetic Induction Agent

Chung WH, Suh BS, Lee SC

  • KMID: 2357998
  • Korean J Anesthesiol.
  • 1973 Dec;6(2):151-158.
A new fluorinated benzodiazepine compound Ro 5-4200 was used for induction in 58 surgical patients to evaluate the possibility of an intravenous anesthetic induction agent (Table 2 and 3). The...
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