Korean J Anesthesiol.  1993 Apr;26(2):207-215. 10.4097/kjae.1993.26.2.207.

Effects of Halothane and Fentanyl Anesthesia on Coronary Endothelial Endothelin-1 Production During Myocardial Ischemia-Reperfusion in Dogs

• Kim KS
• Rhee GY
• Yoo KY
• Ha IH

• KMID: 2239245
• DOI: http://doi.org/10.4097/kjae.1993.26.2.207

Abstract

Endothelin(ET), is the most potent endogenous vasoconstrictor. Myocardial ischemia and chemical stimuli including calcium ionophores are known to release ET-1. Recently, halothane has been shown to block calcium channel. Thus, halothane might attenuate coronary endothelial ET-1 production during myocardial ischemia-reperfusion. To test this hypothesis, we measured plasma ET-1 level continuously in open chest dogs subjected to 15 min of left anterior coronary arterial occlusion and 1 hour of reperfusion during fentanly(n=8) or halothane(n=7) anesthesia. The results were as follows. I) Baseline ET-1 levels of both femoral artery and great cardiac vein in the halothane group were lower than in the fentanly group(NS). 2) ET-1 level of femoral artery and great coronary vein in both halothane and fentanyl group remained unchanged 10 min into ischemia. 3) Coronary blood flow increased by 325, 250% in the halothane group and by 315, 258% in the fentanly group 2, 5 min into reperfusion, respectively. 4) ET-1 production increased from baseline of -2.9+/-1.7 pg/min to 66.0+/-21.5(p<0.05), 20.8+/-5.1 (p<0.01), 13.2+/-6.2(p<0.05) pg/min 5, 15, 30 min into reperfusion, respectively in the fentanyl group, but it remained unchanged from baseline of 0.8+/-3.1 pg/min in the halothane group. These findings suggest that ET-1 production or release is diminished by halothane during myocardial ischemia-reperfusion. Thus, halothane provides an advantage over fentanyl in patients with myocarial ischemic episodes.

Keyword

Anesthetics; Volatile; halothane; Analgesics; fentanyl; Myocardial ischemia; Endothelin

MeSH Terms

Analgesics
Anesthesia*
Anesthetics
Animals
Calcium Channels
Calcium Ionophores
Coronary Vessels
Dogs*
Endothelin-1*
Endothelins
Femoral Artery
Fentanyl*
Halothane*
Humans
Ischemia
Myocardial Ischemia
Plasma
Reperfusion
Thorax
Veins
Analgesics
Anesthetics
Calcium Channels
Calcium Ionophores
Endothelin-1
Endothelins
Fentanyl
Halothane