Korean J Anesthesiol.  1996 Aug;31(2):156-166. 10.4097/kjae.1996.31.2.156.

Effect of High-dose Fentanyl Versus Propofol-Fentanyl Anesthesia on Functional Recovery of Stunned Myocardium in Dogs

• Park CJ
• Yoo KY
• Yoon JS

• KMID: 2237778
• DOI: http://doi.org/10.4097/kjae.1996.31.2.156

Abstract

BACKGROUND: The purpose of this study was to evaluate the effects of propofol-fentanyl anesthesia in comparison with fentanyl alone on the functional recovery of postischemic reperfused myocardium and on the incidence of ischemia-reperfusion arrhythmia in an open-chest canine model.
METHODS
Dogs were subjected to 15 minutes of left anterior descending coronary artery (LAD) occlusion followed by 3 hour of reperfusion during fentanyl (n=12) or propofol plus fentanyl (n=11) anesthesia. Regional myocardial contractility was evaluated using systolic shortening (%SS), the preload recruitable stroke work slope (Mw), intramyocardial pressure (IMPs), and regional stroke work area (RSWA).
RESULTS
Dogs anesthetized with propofol-fentanyl had a significantly lower regional (%SS, Mw, IMPs, and RSWA) and global myocardial contractility (cardiac index, mean aortic pressure and left ventricular dP/dt) than fentanyl anesthetized dogs during pre-occlusion baseline. LAD occlusion produced a significant reduction in the regional contractile functions (%SS, Mw, IMPs, and RSWA) in both groups. During reperfusion, gradual return of the regional contractile functions (%SS, Mw, IMPs, RSWA) toward their respective baselines were observed without any differences between the groups. However, ventricular fibrillation associated with LAD occlusion was lower in the propofol-fentanyl group than in the fentanyl group (zero vs 33%, p<0.05).
CONCLUSIONS
Propofol supplementation over moderate-dose fentanyl reduces reperfusion arrhythmia during coronary occlusion and subsequent reperfusion but does not improve functional recovery of post-ischemic, reperfused myocardium compared with high-dose fentanyl anesthesia in dogs.

Keyword

Heart myocardial ischemia; arrhythmia; myocardial contractility; Anesthetic; Intravenous fentanyl; propofol

MeSH Terms

Anesthesia*
Animals
Arrhythmias, Cardiac
Arterial Pressure
Coronary Occlusion
Coronary Vessels
Dogs*
Fentanyl*
Incidence
Myocardial Stunning*
Myocardium
Propofol
Reperfusion
Stroke
Ventricular Fibrillation
Fentanyl
Propofol