Korean J Anesthesiol.  1994 Jul;27(7):669-677. 10.4097/kjae.1994.27.7.669.

Effects of Halothane on Endothelin-1 Production in coronary Circulation following Myocardial Ischemia-Reperfusion in Dogs

• Kim BR
• Yoon MH
• Yoo KY
• Park CJ

• KMID: 2237883
• DOI: http://doi.org/10.4097/kjae.1994.27.7.669

Abstract

Endothelin (ET), a vascular endothelium derived contracting factor, provokes a strong and long lasting contraction of blood vessels, including coronary artery. Chemical stirnuli such as Ca++ ionophore (in vitro) and myocardial ischemia (in vivo) are known to promote the production of ET. Since halothane has recently been shown to block Ca++ channel, it might blunt ET-1 release or production from ischemic myocardium. To test this hypothesis, open-chest dogs underwent eitber 15 minutes (n=7) of the left anterior descending coronary artery (LAD) occlusion or 30 minutes (n=7) and 120 minutes of reperfusion under the halothane anesthesia. Plasma concentration of ET-1 in the femoral artery (FA) and the great cardiac vein (CV) draining ischemic myocardium was measured using radioimmunoas-say. ET-1 production (pg/mL) was calculated by substrating the ET-1 levels in FA from those in CV. The results were as follows; 1) Baseline ET-1 levels in FA and CV were similar in both groups. 2) ET-1 levels in FA and CV remained unchanged during myocardial ischemia in both groups. 3) ET-1 production significantly increased from baseline at 30, 60 and 120 min into reperfusion, respectively, in the 30 min group, whereas no significant changes were observed from baseline in the 15 min group. These findings indicate that halothane may blunt, but could not block the production or release of ET-1 completely during myocardial ischemia-reperfusion, especially in the case of prolonged coronary arterial occlusion.

Keyword

Endothelin; Myocardial ischemia; Halothane

MeSH Terms

Anesthesia
Animals
Blood Vessels
Coronary Circulation*
Coronary Vessels
Dogs*
Endothelin-1*
Endothelins
Endothelium, Vascular
Femoral Artery
Halothane*
Myocardial Ischemia
Myocardium
Plasma
Reperfusion
Veins
Endothelin-1
Endothelins
Halothane