Korean J Anesthesiol.  2005 Jun;48(6):587-591. 10.4097/kjae.2005.48.6.587.

Effects of a Combination of Nicardipine and Alfentanil on Hemodynamic Response after Endotracheal Intubation

• Kim CM
• Jeong ST
• Kim SJ
• Bae HB
• Choi JI
• Jeong SW
• Chung SS
• Yoo KY
• Jeong CY
• Yoon MH

• KMID: 2238910
• DOI: http://doi.org/10.4097/kjae.2005.48.6.587

Abstract

BACKGROUND: The present study was designed to examine the effect of a combination of nicardipine and low dose alfentanil on hemodynamic response following endotracheal intubation.
METHODS
Thirty patients (20-65 yr) were assigned randomly to receive nicardipine (N: 20microgram/kg) or a combination of nicardipine and low dose of alfentanil (NA: nicardipine 10microgram/kg and alfentanil 5microgram/kg). Systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) were measured at 1, 2 min after anesthetic induction, and every minute for 5 min after intubation.
RESULTS
The magnitude of increases in SBP and DBP were non-significantly smaller in the NA group than in the N group, and increase in HR were significantly lower in the NA group.
CONCLUSIONS
These results indicate that the nicardipine with alfentanil combination was more effective than nicardipine alone at attenuating blood pressure and heart rate increases following intubation.

Keyword

alfentanil; nicardipine; intubation; systolic blood pressure; diastolic blood pressure; heart rate

MeSH Terms

Alfentanil*
Blood Pressure
Heart Rate
Hemodynamics*
Humans
Intubation
Intubation, Intratracheal*
Nicardipine*
Alfentanil
Nicardipine