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Use of methylene blue in vasoplegic syndrome that developed during non-cardiac surgery: A case report

Oh ID, Shin E, Jeon JM, Woo H, Choi JH

BACKGROUND: Vasoplegic syndrome is an increasingly recognized disease in perioperative medicine and is characterized by severe hypotension, normal or elevated cardiac output, and decreased systemic vascular resistance. It occurs commonly...
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The relaxant effect of nicardipine on the isolated uterine smooth muscle of the pregnant rat

Kim DJ, Hwang MH, An TH, Jung KT

BACKGROUND: Nicardipine, a calcium channel blocker, is used to treat hypertension in pregnancy or preterm labor. The current study was conducted to investigate the relaxant effects of nicardipine on the...
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Endovascular Treatment of Symptomatic Vasospasm after Aneurysmal Subarachnoid Hemorrhage: A Three-year Experience

Park ES, Kim DW, Kang SD

OBJECTIVE: The cause of severe clinical vasospasm after aneurysmal subarachnoid hemorrhage remains unknown, despite extensive research over the past 30 years. However, the intra-arterial administration of vasodilating agents and balloon...
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Gintonin facilitates catecholamine secretion from the perfused adrenal medulla

Na SY, Kim KH, Choi MS, Ha KS, Lim DY

The present study was designed to investigate the characteristics of gintonin, one of components isolated from Korean Ginseng on secretion of catecholamines (CA) from the isolated perfused model of rat...
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Hypertensive crisis in children: an experience in a single tertiary care center in Korea

Lee GH, Lee IR, Park SJ, Kim JH, Oh JY, Shin JI

BACKGROUND: Hypertensive crisis is a medical emergency that can cause acute damage to multiple end-organs. However, relatively little is known on the etiology, treatment, and outcomes of hypertensive crisis in...
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Comparison of electrophysiological effects of calcium channel blockers on cardiac repolarization

Lee HA, Hyun SA, Park SG, Kim KS, Kim SJ

Dihydropyridine (DHP) calcium channel blockers (CCBs) have been widely used to treat of several cardiovascular diseases. An excessive shortening of action potential duration (APD) due to the reduction of Ca2+...
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New direct-acting antivirals for the treatment of chronic hepatitis C

Jeong SH

The successful development of direct-acting antivirals (DAA) represents a breakthrough in the treatment of hepatitis C virus (HCV) infection. Pegylated interferon alpha and ribavirin combination therapy for 24-48 weeks was...
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Dexmedetomidine and remifentanil in the perioperative management of an adolescent undergoing resection of pheochromocytoma: A case report

Jung JW, Park JK, Jeon SY, Kim YH, Nam SH, Choi YG, Bang SR

A 15-year-old adolescent with unilateral multiple adrenal pheochromocytoma had an episode of subcortical intracerebral hemorrhage and seizure 6 weeks before the surgery. He was pretreated with terazosin, losartan, atenolol and...
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Antihypertensive Treatment of Acute Intracerebral Hemorrhage by Intravenous Nicardipine Hydrochloride: Prospective Multi-Center Study

Hwang SK, Kim JS, Kim JH, Hong CK, Yang KH

The authors performed a multicenter prospective study to evaluate the feasibility and safety of intravenous nicardipine hydrochloride for acute hypertension in patients with intracerebral hemorrhage (ICH). This study included 88...
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Effectiveness of Nicardipine for Blood Pressure Control in Patients with Subarachnoid Hemorrhage

Kim SY, Kim SM, Park MS, Kim HK, Park KS, Chung SY

OBJECTIVE: The purpose of the study is to determine the effectiveness and safety of nicardipine infusion for controlling blood pressure in patients with subarachnoid hemorrhage (SAH). METHODS: We prospectively evaluated 52...
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The Effect of Intra-Arterial Low-Dose Nicardipine for the Treatment of Aneurysmal Subarachnoid Hemorrhage-associated Vasospasm

Sung JK, Kang CW, Kwon HJ, Koh HS, Choi SW, Song SH

  • KMID: 2256731
  • Korean J Cerebrovasc Surg.
  • 2011 Sep;13(3):184-193.
OBJECTIVE: Delayed cerebral ischemia due to vasospasm after aneurysmal subarachnoid hemorrhage (SAH) is a leading cause of morbidity and mortality. Recent reports have confirmed that intra-arterial infusion of calcium-channel blockers,...
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Effect of Calcium Channel Blocker on Primary Rat Cardiomyoblasts and Cardiac Rate in Vitro

Park YM, Hwang Y, Cho TE, Yoo SJ

  • KMID: 1818923
  • J Korean Soc Emerg Med.
  • 2011 Aug;22(4):335-342.
PURPOSE: This work was intended to establish experimental conditions for monitoring the effect of ischemic/reperfusion injury on the beating capability of, and apoptotic damage to, primary rat cardiomyoblasts, and to...
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The relationship of preoperative N-terminal pro-BNP and the amount of hemodynamic drugs used during noncardiac surgery

Lim CS, Shin YS

  • KMID: 2169189
  • Anesth Pain Med.
  • 2011 Jan;6(1):28-31.
BACKGROUND: BNP and NT-proBNP are very useful predictor of perioperative cardiac events. The authors therefore performed a retrospective study about the relationship between NT-proBNP and intraoperative hemodynamic stability. METHODS: The authors...
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The Comparison of the Effects of Nicardipine and Remifentanil on Fluctuation of Blood Pressure during Controlled Hypotension

Kim ES, Hwang BY, Kim CH

BACKGROUND: Controlled hypotension is used to reduce bleeding and improve surgical conditions during surgery. Nicardipine and remifentanil have been used to induce controlled hypotension in healthy patients. This study compared...
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Prolonged effect of nicardipine used for deliberate hypotension in scoliosis surgery: A case report

Oh SC, Chung K, Cho HS, Ryu KH, Cho SA, Lee SM

  • KMID: 1803582
  • Anesth Pain Med.
  • 2010 Oct;5(4):317-320.
Postoperative respiratory complications following scoliosis surgery are high incidence. In this case, fifty year-old male patient was admitted for thoracolumbar screw fixations and developed postoperative pulmonary edema. This was most...
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Optimal dose of esmolol in combination with nicardipine to stabilize cardiovascular response during anesthetic induction in ambulatory patients

Joo J, Lee J, Kim JE, Park J

  • KMID: 1803576
  • Anesth Pain Med.
  • 2010 Oct;5(4):288-294.
BACKGROUND: We conducted this study to determine the optimal dose of esmolol in combination with nicardipine to block undesirable cardiovascular responses effectively during endotracheal intubation in patients undergoing ambulatory surgery. METHODS:...
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Does a single dose of intravenous nicardipine or nimodipine affect the bispectral index following rapid sequence intubation?

Lee JJ, Kim JA, Ahn HJ, Kim JK, Yang M, Choi SJ, Kim HS, Yang SH

BACKGROUND: Theoretically, L-type calcium channel blockers could modulate anesthetic effects. Nicardipine does not affect the bispectral index (BIS), but nimodipine, which can penetrate the blood-brain barrier, has not been studied....
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The effects of calcium channel blockers pretreatment on blood potassium level after the administration of succinylcholine in hypertensive patients

Ko JH, An TH

BACKGROUND: The aim of the present study was to evaluate whether calcium channel blockers pretreatment increase blood potassium level after the administration of succinylcholine in hypertensive patients. METHODS: Eighty hypertensive...
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Nicardipine is more effective than esmolol at preventing blood pressure increases during emergence from total intravenous anesthesia

Park SH, Do SH, Shin HY, Jeon YT, Hwang JW, Han SH

BACKGROUND: This prospective, randomized, double-blind study was undertaken to compare prophylactic nicardipine infusion with esmolol infusion to determine their effects on the control of hemodynamic response during emergence from total...
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A case of gingival hyperplasia caused by felodipine

Park JS, Lee CH, Kim NR, No DH, Kim DH, Choi SY, Jeong JH

  • KMID: 2081662
  • Korean J Med.
  • 2009 Apr;76(Suppl 1):S93-S96.
Felodipine is a calcium channel blocker that is used in the management of hypertension. Calcium channel blockers, along with phenytoin and cyclosporin, are implicated as a cause of gingival hyperplasia....
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