J Korean Ophthalmol Soc.
1999 Dec;40(12):3361-3367.
The Effects of Nicardipine in Experimentally-induced Retinal Ischemia-reperfusion Injury in Cats and Rabbits
- Affiliations
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- 1Department of Ophthalmology, School of Medicine, Kyungpook National University.
- 2Department of Ophthalmology, Fatima General Hospital, Taegu, Korea.
Abstract
- We investigated the effect of nicardipine on the retinal ischemia-reperfusion injury. After intravenous administration[30 microgram/kg] or intravitreal injection[10microgram] of nicardipine, total retinal ischemia for 60~90 minutes was induced in the left eye of cat or rabbit. Electroretinogram[ERG] including oscillatory potentials[OPs] was recorded from both eyes simultaneously prior to administration of nicardipine, and 1 hour, 1 day, 3 day, 1 week, and 2 weeks after reperfusion. In cats, the electroretinogram improved by intravenous or intravitreal injection of nicardipine. However, the degree was not statistically significant. In rabbits having intravitreal injection of nicardipine, marked improvement in recovery was achieved in post-reperfusion 1 hour b-wave and 3 day, 7 day SOP[summed amplitude of oscillatory potentials]. Difference of nicardipine effect on the retinal ischemiareperfusion injury between cats and rabbits can be attributed to the differences in the distribution of voltage-sensitive calcium channels.
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