- The optimal model of reperfusion injury in vitro using H9c2 transformed cardiac myoblasts
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Son E, Lee D, Woo CW, Kim YH
- KMID: 2471039
- Korean J Physiol Pharmacol.
- 2020 Mar;24(2):173-183.
- doi: 10.4196/kjpp.2020.24.2.173
An in vitro model for ischemia/reperfusion injury has not been well-established. We hypothesized that this failure may be caused by serum deprivation, the use of glutamine-containing media, and absence of... -
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- MiR-484 Protects Rat Myocardial Cells from Ischemia-Reperfusion Injury by Inhibiting Caspase-3 and Caspase-9 during Apoptosis
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Liu H, Li S, Jiang W, Li Y
- KMID: 2470910
- Korean Circ J.
- 2020 Mar;50(3):250-263.
- doi: 10.4070/kcj.2019.0107
BACKGROUND AND OBJECTIVES: To reveal the detail mechanism of miR-484 on myocardial ischemia-reperfusion (MI/R) injury. METHODS: Rats model of MI/R injury was established based on control (Con; sham operate) group, ischemia-reperfusion... -
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- Fimasartan attenuates renal ischemia-reperfusion injury by modulating inflammation-related apoptosis
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Cho JH, Choi SY, Ryu HM, Oh EJ, Yook JM, Ahn JS, Jung HY, Choi JY, Park SH, Kim CD, Kim YL
- KMID: 2430088
- Korean J Physiol Pharmacol.
- 2018 Nov;22(6):661-670.
- doi: 10.4196/kjpp.2018.22.6.661
Fimasartan, a new angiotensin II receptor antagonist, reduces myocyte damage and stabilizes atherosclerotic plaque through its anti-inflammatory effect in animal studies. We investigated the protective effects of pretreatment with fimasartan... -
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- Hypoxic Preconditioned Mesenchymal Stromal Cell Therapy in a Rat Model of Renal Ischemia-reperfusion Injury: Development of Optimal Protocol to Potentiate Therapeutic Efficacy
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Jang MJ, You D, Park JY, Kim K, Aum J, Lee C, Song G, Shin HC, Suh N, Kim YM, Kim CS
- KMID: 2429548
- Int J Stem Cells.
- 2018 Nov;11(2):157-167.
- doi: 10.15283/ijsc18073
Although previous and ongoing clinical studies have used stromal cells during renal ischemia-reperfusion injury (IRI), there is little consensus regarding the optimal protocol. We aimed to optimize the protocol for... -
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- Beneficial Role of Hydrogen Sulfide in Renal Ischemia Reperfusion Injury in Rats
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Choi EK, Park SH, Lim JA, Hong SW, Kwak KH, Park SS, Lim DG, Jung H
- KMID: 2419730
- Yonsei Med J.
- 2018 Oct;59(8):960-967.
- doi: 10.3349/ymj.2018.59.8.960
PURPOSE: Hydrogen sulfide (H2S) is an endogenous gaseous molecule with important physiological roles. It is synthesized from cysteine by cystathionine γ-lyase (CGL) and cystathionine β-synthase (CBS). The present study examined... -
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- Extracellular Vesicles Derived from Hypoxic Human Mesenchymal Stem Cells Attenuate GSK3β Expression via miRNA-26a in an Ischemia-Reperfusion Injury Model
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Park H, Park H, Mun D, Kang J, Kim H, Kim M, Cui S, Lee SH, Joung B
- KMID: 2415532
- Yonsei Med J.
- 2018 Aug;59(6):736-745.
- doi: 10.3349/ymj.2018.59.6.736
PURPOSE: Bioactive molecules critical to intracellular signaling are contained in extracellular vesicles (EVs) and have cardioprotective effects in ischemia/reperfusion (IR) injured hearts. This study investigated the mechanism of the cardioprotective... -
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- Dual Effect of Hepatic Macrophages on Liver Ischemia and Reperfusion Injury during Liver Transplantation
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Lu TF, Yang TH, Zhong CP, Shen C, Lin WW, Gu GX, Xia Q, Xu N
- KMID: 2414553
- Immune Netw.
- 2018 Jun;18(3):e24.
- doi: 10.4110/in.2018.18.e24
Ischemia-reperfusion injury (IRI) is a major complication in liver transplantation (LT) and it is closely related to the recovery of grafts' function. Researches has verified that both innate and adaptive... -
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- Quantitative evaluation of renal parenchymal perfusion using contrast-enhanced ultrasonography in renal ischemia-reperfusion injury in dogs
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Lee G, Jeon S, Lee SK, Cheon B, Moon S, Park JG, Cho KO, Choi J
- KMID: 2398510
- J Vet Sci.
- 2017 Dec;18(4):507-514.
- doi: 10.4142/jvs.2017.18.4.507
This study evaluated whether renal perfusion changes can be noninvasively estimated by using contrast-enhanced ultrasonography (CEUS) in renal ischemia-reperfusion injury and investigated the correlation between renal perfusion measured by CEUS... -
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- The optimal duration of ischemic preconditioning for renal ischemia-reperfusion injury in mice
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Choi HS, Hwang JK, Kim JG, Hwang HS, Lee SJ, Chang YK, Kim JI, Moon IS
- KMID: 2392371
- Ann Surg Treat Res.
- 2017 Oct;93(4):209-216.
- doi: 10.4174/astr.2017.93.4.209
PURPOSE: The aim of the present study was to investigate the protective effects of ischemic preconditioning for different periods of time and to elucidate the optimal safe ischemic preconditioning time... -
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- Immunologic Mechanism of Ischemia Reperfusion Injury in Transplantation
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Lee JS
- KMID: 2392416
- J Korean Soc Transplant.
- 2017 Sep;31(3):99-110.
- doi: 10.4285/jkstn.2017.31.3.99
Ischemia-reperfusion injury (IRI) is an inevitable consequence of organ transplantation that has major consequences for graft-and patient survival. During transplantation procedures, allografts are exposed to various periods of complete ischemia.... -
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- Effects of Remote Ischemic Conditioning Methods on Ischemia-Reperfusion Injury in Muscle Flaps: An Experimental Study in Rats
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Keskin D, Unlu RE, Orhan E, Erkilinç , Bogdaycioglu N, Yilmaz FM
- KMID: 2392310
- Arch Plast Surg.
- 2017 Sep;44(5):384-389.
- doi: 10.5999/aps.2017.44.5.384
BACKGROUND: The aim of this study was to investigate the effects of remote ischemic conditioning on ischemia-reperfusion injury in rat muscle flaps histopathologically and biochemically. METHODS: Thirty albino rats were divided... -
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- Spermidine is protective against kidney ischemia and reperfusion injury through inhibiting DNA nitration and PARP1 activation
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Kim J
- KMID: 2390481
- Anat Cell Biol.
- 2017 Sep;50(3):200-206.
- doi: 10.5115/acb.2017.50.3.200
Kidney ischemia and reperfusion injury (IRI) is associated with a high mortality rate, which is attributed to tubular oxidative and nitrative stresses; however, an effective approach to limit IRI remains... -
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- RhGLP-1 (7–36) protects diabetic rats against cerebral ischemia-reperfusion injury via up-regulating expression of Nrf2/HO-1 and increasing the activities of SOD
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Fang Y, Liu X, Zhao L, Wei Z, Jiang D, Shao H, Zang Y, Xu J, Wang Q, Liu Y, Peng Y, Yin X
- KMID: 2388693
- Korean J Physiol Pharmacol.
- 2017 Sep;21(5):475-485.
- doi: 10.4196/kjpp.2017.21.5.475
The present study aimed to explore the neuroprotective effect and possible mechanisms of rhGLP-1 (7–36) against transient ischemia/reperfusion injuries induced by middle cerebral artery occlusion (MCAO) in type 2 diabetic... -
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- The renoprotective effects of mannitol and udenafil in renal ischemia-reperfusion injury model
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Özlülerden Y, Toktaş C, Aybek H, Küçükatay V, Şen Türk N, Zumrutbas
- KMID: 2410297
- Investig Clin Urol.
- 2017 Jul;58(4):289-295.
- doi: 10.4111/icu.2017.58.4.289
PURPOSE: The aim of this study was to investigate and compare the effects of udenafil and mannitol in an experimental renal ischemia-reperfusion (I/R) injury model. MATERIALS AND METHODS: A total of... -
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- Neuroprotection of Dexmedetomidine against Cerebral Ischemia-Reperfusion Injury in Rats: Involved in Inhibition of NF-κB and Inflammation Response
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Wang L, Liu H, Zhang L, Wang G, Zhang M, Yu Y
- KMID: 2386904
- Biomol Ther.
- 2017 Jul;25(4):383-389.
- doi: 10.4062/biomolther.2015.180
Dexmedetomidine is an α2-adrenergic receptor agonist that exhibits a protective effect on ischemia-reperfusion injury of the heart, kidney, and other organs. In the present study, we examined the neuroprotective action... -
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- Protective Role of Fucoidan in Cerebral Ischemia-Reperfusion Injury through Inhibition of MAPK Signaling Pathway
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Che N, Ma Y, Xin Y
- KMID: 2378805
- Biomol Ther.
- 2017 May;25(3):272-278.
- doi: 10.4062/biomolther.2016.098
Fucoidan has been reported to exhibit various beneficial activities ranging from to antivirus and anticancer properties. However, little information is available about the effects of fucoidan on cerebral ischemia-reperfusion injury... -
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- Inhibiting Cytochrome C Oxidase Leads to Alleviated Ischemia Reperfusion Injury
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Yang Z, Duan Z, Yu T, Xu J, Liu L
- KMID: 2377459
- Korean Circ J.
- 2017 Mar;47(2):193-200.
- doi: 10.4070/kcj.2016.0137
BACKGROUND AND OBJECTIVES: The overall purpose of this study was to investigate the role of cytochrome C oxidase (CcO) in preventing ischemia reperfusion-induced cardiac injury through gaseous signaling molecule pathways. MATERIALS... -
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- Lower limb compartment syndrome by reperfusion injury after treatment of arterial thrombosis post-laparoscopic radical hysterectomy and pelvic lymph node dissection for cervical cancer
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Yeon J, Jung YW, Yang SS, Kang BH, Lee M, Ko YB, Yang JB, Lee KH, Yoo HJ
- KMID: 2372809
- Obstet Gynecol Sci.
- 2017 Mar;60(2):223-226.
- doi: 10.5468/ogs.2017.60.2.223
Compartment syndrome is a clinical condition associated with decreased blood circulation that can lead to swelling of tissue in limited space. Several factors including lithotomy position, prolonged surgery, intermittent pneumatic... -
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- Concise Bedside Surgical Management of Profound Reperfusion Injury after Vascular Reconstruction in Severe Trauma Patient: Case Report
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Chung HJ, Kim SY, Byun CS, Kwon KY, Jung PY
- KMID: 2378461
- J Korean Soc Traumatol.
- 2016 Dec;29(4):204-208.
- doi: 10.20408/jti.2016.29.4.204
For an orthopaedic surgeon, the critical decisions to either amputate or salvage a limb with severe crushing injury with progressive ischemic change due to arterial rupture or occlusion can become... -
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- Curcumin protects against the intestinal ischemia-reperfusion injury: involvement of the tight junction protein ZO-1 and TNF-alpha related mechanism
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Tian S, Guo R, Wei S, Kong Y, Wei X, Wang W, Shi X, Jiang H
- KMID: 2388670
- Korean J Physiol Pharmacol.
- 2016 Mar;20(2):147-152.
- doi: 10.4196/kjpp.2016.20.2.147
Present study aimed to investigate the eff ect of curcumin-pretreatment on intestinal I/R injury and on intestinal mucosa barrier. Thirty Wistar rats were randomly divided into: sham, I/R, and curcumin... -
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