Anesth Pain Med.
2018 Jan;13(1):10-17. 10.17085/apm.2018.13.1.10.
Kidney transplantation and ischemic conditioning: past, present and future perspectives
- Affiliations
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- 1Department of Anesthesiology and Pain Medicine, School of Medicine, Kyungpook National University, Daegu, Korea. wing2392@naver.com
- KMID: 2436049
- DOI: http://doi.org/10.17085/apm.2018.13.1.10
Abstract
- Kidney transplantation is one of the treatments for the end-stage renal disease for various reasons. Ischemia-reperfusion injury (IRI) is an important mechanism of injury associated with acute rejection, delayed graft function, late graft failure, and graft loss in renal transplantation. Ischemic conditioning, which applies brief ischemia and reperfusion before, during, or after IRI is one of the protecting IRI strategies. Although animal studies have demonstrated the efficacy of IRI, the translation into beneficial clinical outcomes to humans is still controversial. By investigating the usefulness of ischemic conditioning in kidney transplantation in the present work, we aim to review overall ischemic conditioning and desire to predict the future of ischemic conditioning.
