Anesth Pain Med.  2018 Jan;13(1):10-17. 10.17085/apm.2018.13.1.10.

Kidney transplantation and ischemic conditioning: past, present and future perspectives

• Jung H

• KMID: 2436049
• DOI: http://doi.org/10.17085/apm.2018.13.1.10

Abstract

Kidney transplantation is one of the treatments for the end-stage renal disease for various reasons. Ischemia-reperfusion injury (IRI) is an important mechanism of injury associated with acute rejection, delayed graft function, late graft failure, and graft loss in renal transplantation. Ischemic conditioning, which applies brief ischemia and reperfusion before, during, or after IRI is one of the protecting IRI strategies. Although animal studies have demonstrated the efficacy of IRI, the translation into beneficial clinical outcomes to humans is still controversial. By investigating the usefulness of ischemic conditioning in kidney transplantation in the present work, we aim to review overall ischemic conditioning and desire to predict the future of ischemic conditioning.

Keyword

Ischemia-reperfusion injury; Ischemic conditioning; Kidney; Transplantation

MeSH Terms

Animals
Delayed Graft Function
Humans
Ischemia
Kidney Failure, Chronic
Kidney Transplantation*
Kidney*
Reperfusion
Reperfusion Injury
Transplantation
Transplants

Figure

• 

  Fig. 1 Ischemic conditioning. IRI: ischemia-reperfusion injury.

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