Korean J Anesthesiol.  2006 Jan;50(1):48-53. 10.4097/kjae.2006.50.1.48.

The Effect of Nicardipine on Hemodynamic Responses to Tracheal Intubation during Inhalation with Sevoflurane

• Jin IB
• Lim HS
• Son JS
• Han YJ

• KMID: 2237476
• DOI: http://doi.org/10.4097/kjae.2006.50.1.48

Abstract

BACKGROUND: Laryngoscopy and tracheal intubation often provoke an undesirable increase in blood pressure and heart rate. Nicardipine-induced reduction in blood pressure was greater with inhalational anesthetics than nicardipine alone. This study was designed to determine the optimal dose of nicardipine for acceptable hemodnamic change during inhalation with sevoflurane.
METHODS
Eighty ASA physical status 1 patients were randomly allocated into four groups of twenty patients. Tracheal intubation under direct laryngoscopy was performed. After intravenous thiopental 5 mg/kg, vecuronium 0.13 mg/kg 5, 10 or 15microgram/kg of nicardipine was given intravenously followed by mask ventilation of three minutes with sevoflurane, nitrous oxide and oxygen. Heart rate and blood pressure were measured at the period of baseline, preintubation, immediately after intubation, 1, 2, 4, 6 and 9 minutes following intubation.
RESULTS
After tracheal intubation, the increase of systolic blood pressure was suppressed significantly by nicardipine 10 and 15microgram/kg group compared with the control group. The increase of heart rate was greatest in the nicardipine 15microgram/kg group.
CONCLUSIONS
We suggest that the appropriate dose of nicardipine during induction with sevoflurane for attenuation of pressor responses to laryngoscopy and intubation in healthy patients is 10microgram/kg.

Keyword

intubation; nicardipine; sevoflurane

MeSH Terms

Anesthetics
Blood Pressure
Heart Rate
Hemodynamics*
Humans
Inhalation*
Intubation*
Laryngoscopy
Masks
Nicardipine*
Nitrous Oxide
Oxygen
Thiopental
Vecuronium Bromide
Ventilation
Anesthetics
Nicardipine
Nitrous Oxide
Oxygen
Thiopental
Vecuronium Bromide