Korean J Anesthesiol.  2005 Sep;49(3):327-331. 10.4097/kjae.2005.49.3.327.

Effect of Preventive Nicardipine on Hemodynamics Induced by Pneumoperitoneum during Laparoscopic Cholecystectomy

• Jeong JH
• Lim DG

• KMID: 2299130
• DOI: http://doi.org/10.4097/kjae.2005.49.3.327

Abstract

BACKGROUND: Pneumoperitoneum for a laparoscopic cholecystectomy induces hemodynamic changes. The present study investigated the effect of preventive nicardipine on the hemodynamics induced by pneumoperitoneum during a laparoscopic cholecystectomy.
METHODS
Forty five patients, scheduled to undergo laparoscopic cholecystectomy, were selected, and divided into three groups; the control group (C; normal saline infusion), the nicardipine bolus injection group (NB; 20microgram/kg nicardipine infusion, 1 min before skin incision) and the nicardipine continuous infusion group (NI; 2microgram/kg/min continuous infusion, from the time of endotracheal intubation to pneumoperitoneum). The blood pressure, heart rate, cardiac output and systemic vascular resistance were measured; at preincision, and at 5, 10 and 15 min after insufflation and at 5 min after exsufflation.
RESULTS
Nicardipine injection attenuated increases in the blood pressure, systemic vascular resistance after pneumoperitoneum, and didn't attenuate decrease in the cardiac output.
CONCLUSIONS
A preventive nicardipine injection is effective in attenuating the hemodynamic change after pneumoperitoneum during a laparoscopic cholecystectomy, especially attenuated the systemic vascular resistance and blood pressure increase.

Keyword

cholecystectomy; hemodynamics; laparoscopy; nicardipine; pneumoperitoneum

MeSH Terms

Blood Pressure
Cardiac Output
Cholecystectomy
Cholecystectomy, Laparoscopic*
Heart Rate
Hemodynamics*
Humans
Insufflation
Intubation, Intratracheal
Laparoscopy
Nicardipine*
Pneumoperitoneum*
Skin
Vascular Resistance
Nicardipine