Anesth Pain Med.  2008 Jan;3(1):17-21.

Hemodynamic Effects of Nicardipine Measured by Esophageal Doppler Monitor during Gynecologic Laparoscopic Surgery

• Shim HS
• Cho JY
• Shin MK

Abstract

BACKGROUND: The authors performed this study to investigate the hemodynamic effect of nicardipine using an esophageal Doppler monitor (EDM) during gynecologic laparoscopic surgery.
METHODS
Forty patients scheduled to undergo gynecologic laparoscopic surgery, were divided into two groups; the control group (Group C) and the nicardipine group (Group N). Pneumoperitoneum was initiated using CO2 gas and the intraperitoneal pressure was kept under 12 mmHg. Hemodynamic parameters at critical points were measured using EDM, i.e., before skin incision (T1), 5, 10 and 15 min after the initiation of pneumoperitoneum (T2, T3 and T4), and 5 min after deflation (T5).
RESULTS
Mean arterial pressure (MAP) was significantly lower in Group N patients than in Group C patients at 5 and 10 min after the initiation of pneumoperitoneum (T2 and T3) (P < 0.05). No significant heart rate (HR) differences were observed between the two study groups. Cardiac output (CO), peak velocity (PV) and corrected flow time (FTC) were significantly higher in Group N at 10 min after the initiation of pneumoperitoneum (T3) (all P < 0.05).
CONCLUSIONS
The nicardipine continuous infusion at 0.5?2.0microg/ kg/min is effective at attenuating hemodynamic changes after pneumoperitoneum during gynecologic laparoscopic surgery.

Keyword

esophageal Doppler monitor; gynecologic laparoscopic surgery; nicardipine; pneumoperitoneum

MeSH Terms

Arterial Pressure
Cardiac Output
Heart Rate
Hemodynamics
Humans
Laparoscopy
Nicardipine
Organothiophosphorus Compounds
Pneumoperitoneum
Skin
Nicardipine
Organothiophosphorus Compounds