Korean J Anesthesiol.  2008 Jul;55(1):20-25. 10.4097/kjae.2008.55.1.20.

The effects of alfentanil pretreatment on vascular pain and cardiovascular response associated with intravenous

• Kim OH
• Yoon MH
• Jeong CW
• Lee HG
• Kim WM

• KMID: 1782515
• DOI: http://doi.org/10.4097/kjae.2008.55.1.20

Abstract

BACKGROUND: The intravenous injection of rocuronium bromide is often painful, and different methods have been used to minimize the incidence and severity of this pain. This study determined the effective dose of alfentanil to minimize the injection pain of rocuronium and the cardiovascular response after endotracheal intubation.
METHODS
Eighty ASA physical status 1 and 2 adult patients were divided into four groups. Sixty seconds before administering rocuronium 0.6 mg/kg, the groups were given 10 ml of intravenous normal saline or alfentanil 10, 15, and 20microgram/kg. Pain was assessed after rocuronium injection. The mean arterial pressure and heart rate were measured before induction and before and after intubation.
RESULTS
Both 15 and 20microgram/kg alfentanil minimized the rocuronium injection pain, although 20microgram/kg alfentanil caused an undesirable decrease in the mean arterial pressure.
CONCLUSIONS
A 15microgram/kg bolus of alfentanil may be useful for minimizing the rocuronium injection pain and blunting the cardiovascular response after endotracheal intubation.

Keyword

alfentanil; cardiovascular response; endotracheal intubation; rocuronium; vascular pain

MeSH Terms

Adult
Alfentanil
Androstanols
Arterial Pressure
Heart Rate
Humans
Incidence
Injections, Intravenous
Intubation, Intratracheal
Alfentanil
Androstanols