Korean J Anesthesiol.  2008 Nov;55(5):560-564. 10.4097/kjae.2008.55.5.560.

The effect of ephedrine on blood pressure and heart rate during propofol-alfentanil anesthesia; compare to the awake patients

• Moon SS
• Son JS
• Choe H
• Han YJ
• Lee SK

• KMID: 2242994
• DOI: http://doi.org/10.4097/kjae.2008.55.5.560

Abstract

BACKGROUND
Hypotension and bradycardia in the propofol and alfentanil anesthesia are common during induction and maintenance. Ephedrine has been used to attenuate hypotension and bradycardia in the propofol and alfentanil anesthesia. We designed this study to determine whether propofol and alfentanil anesthesia could affect the blood pressure and heart rate response to intravenous ephedrine when compared with the awake state.
METHODS
Forty patients of ASA physical status 1 or 2 were assigned to one of two groups (Awake vs Propofol-alfentanil [P-A] group). Each patients received ephedrine 0.15 mg/kg after assessment of baseline hemodynamic values. In the awake patients, ephedrine were administered after hemodynamic parameters are stabilized. If hemodynamic parameters are stabilized after intubation, ephedrine were administered in the propofol-alfentanil anesthesia patients. The changes in systolic/diastolic blood pressure (SBP/DBP), mean blood pressure (MBP), and heart rate (HR) were recorded every one minute for 10 minutes.
RESULTS
Ephedrine increased the heart rate significantly in Awake group but not in P-A group. In the P-A group, 3 min after the administration of ephedrine, MBP increased 25.3%. In Awake group, 2 min after the administration of ephedrine, MBP increased only 6.3%.
CONCLUSIONS
We conclude that propofol and alfentanil anesthesia augments the BP response to intravenous ephedrine but not HR.

Keyword

alfentanil; blood pressure; ephedrine; heart rate; propofol

MeSH Terms

Alfentanil
Anesthesia
Blood Pressure
Bradycardia
Ephedrine
Heart
Heart Rate
Hemodynamics
Humans
Hypotension
Intubation
Propofol
Alfentanil
Ephedrine
Propofol