Korean J Anesthesiol.  2004 Nov;47(5):623-628. 10.4097/kjae.2004.47.5.623.

The Effective Dose (ED50, ED95) of Alfentanil to Minimize the Hemodynamic Responses to Laryngoscopy and Endotracheal Intubation

• Park GM
• In JY
• Lee MA
• Kwak HS

• KMID: 2236660
• DOI: http://doi.org/10.4097/kjae.2004.47.5.623

Abstract

BACKGROUND: Intravenous alfentanil is one of the effective methods to minimize the hemodynamic responses to laryngoscopy and endotracheal intubation. The purpose of this study is to get effective dose (ED50, ED95) of alfentanil to minimize the hemodynamic responses to laryngoscopy and endotracheal intubation.
METHODS
Sixty patients were divided into four groups. Each group received intravenous normal saline 5 ml (Control group), alfentanil 10microgram/kg (Al10), alfentanil 20microgram/kg (Al20) and alfentanil 30microgram/kg (Al30), respectively. Mean arterial pressure (MAP) and heart rate (HR) were measured before and after intubation. We considered the doses of alfentanil effective when the increase in MAP and HR after intubation did not exceed 10% of those before intubation.
RESULTS
The ED50 of alfentanil was 12.7 (8.6-16.4)microgram/kg for MAP, 20.1 (15.7-25.6)microgram/kg for HR, respectively. The ED95 of alfentanil was 26.4 (21.7-36.2)microgram/kg for MAP, 38.6 (31.2-56.7)microgram/kg for HR, respectively.
CONCLUSIONS
Alfentanil was effective to minimize the hemodynamic responses to laryngoscopy and endotracheal intubation with its ED50 and ED95 as mentioned earlier.

Keyword

alfentanil; effective dose; hemodynamic responses; intubation; laryngoscopy

MeSH Terms

Alfentanil*
Arterial Pressure
Heart Rate
Hemodynamics*
Humans
Intubation
Intubation, Intratracheal*
Laryngoscopy*
Alfentanil