Korean J Anesthesiol.  1999 Jul;37(1):139-143. 10.4097/kjae.1999.37.1.139.

Effects of Vecuronium and Pancuronium on the Tension of the Smooth Muscle in the Rat Trachea

• Kim SS
• Son YS
• Kim YH
• Yoon SH
• Lee JU
• Kim HJ

• KMID: 2236854
• DOI: http://doi.org/10.4097/kjae.1999.37.1.139

Abstract

BACKGROUND: Vecuronium and Pancuronium have been proven to be associated with nicotinic receptor of skeletal muscle. Generally, nondepolarizing muscle relaxant is associated with contraction of smooth tracheal muscle, but there have been few studies about effects of nondepolarizing muscle relaxant on the smooth tracheal muscle.
METHODS
We studied the acetylcholine dose response curve of the tracheal smooth muscle contraction and effects of propranolol, L-NAME after pretreating with vecuronium and pancuronium.
RESULTS
Vecuronium shifted the acetylcholine dose-response curve of the tracheal contraction to the left, and pancuronium shifted the curve to the right. Vecuronium and Pancuronium reduced the contraction of smooth tracheal muscle with the use carbachol. Propranolol and L-NAME had no effect on the contraction of smooth tracheal muscle after pretreating with vecuronium and pancuronium.
CONCLUSION
We suggest that vecuronium has an anticholinergic effect, while pancuronium has some effect on the muscarinic receptor in addition to its anticholinergic effect.

Keyword

Muscle, acetylcholine, contraction, muscarinic, nicotinic; Neuromuscular relaxants, pancuronium, vecuronium

MeSH Terms

Acetylcholine
Animals
Carbachol
Muscle, Skeletal
Muscle, Smooth*
NG-Nitroarginine Methyl Ester
Pancuronium*
Propranolol
Rats*
Receptors, Muscarinic
Receptors, Nicotinic
Trachea*
Vecuronium Bromide*
Acetylcholine
Carbachol
NG-Nitroarginine Methyl Ester
Pancuronium
Propranolol
Receptors, Muscarinic
Receptors, Nicotinic
Vecuronium Bromide