- Neuroimmune interactions and kidney disease
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Hasegawa S, Inoue T, Inagi R
- KMID: 2457720
- Kidney Res Clin Pract.
- 2019 Sep;38(3):282-294.
- doi: 10.23876/j.krcp.19.014
The autonomic nervous system plays critical roles in maintaining homeostasis in humans, directly regulating inflammation by altering the activity of the immune system. The cholinergic anti-inflammatory pathway is a well-studied... -
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- A Novel Immunomodulatory Mechanism Dependent on Acetylcholine Secreted by Human Bone Marrow-derived Mesenchymal Stem Cells
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Yi TG, Cho YK, Lee HJ, Kim J, Jeon MS, Ham DS, Kim WC, Song SU
- KMID: 2465901
- Int J Stem Cells.
- 2019 Jul;12(2):315-330.
- doi: 10.15283/ijsc18098
BACKGROUND AND OBJECTIVES: Mesenchymal stem cells (MSCs) are used to treat autoimmune or inflammatory diseases. Our aim was to determine the immunomodulatory mechanisms elicited by MSCs during inflammation. METHODS AND RESULTS:... -
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- Melatonin inhibits nicotinic acetylcholine receptor functions in bovine chromaffin cells
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Jo SH, Lee SH, Kim KT, Choi SY
- KMID: 2452747
- Int J Oral Biol.
- 2019 Jun;44(2):50-54.
- doi: 10.11620/IJOB.2019.44.2.50
Melatonin is a neurotransmitter that modulates various physiological phenomena including regulation and maintenance of the circadian rhythm. Nicotinic acetylcholine receptors (nAChRs) play an important role in oral functions including orofacial... -
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- Basal Forebrain Cholinergic-induced Activation of Cholecystokinin Inhibitory Neurons in the Basolateral Amygdala
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Lee S, Kim JH
- KMID: 2451068
- Exp Neurobiol.
- 2019 Jun;28(3):320-328.
- doi: 10.5607/en.2019.28.3.320
The basolateral amygdala (BLA) receives dense projections from cholinergic neurons of the basal forebrain. Acetylcholine can contributes to amygdala-dependent behaviors: formation and extinction of fear memory and appetitive instrumental learning.... -
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- Factors that affect the onset of action of non-depolarizing neuromuscular blocking agents
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Kim YB, Sung TY, Yang HS
- KMID: 2395603
- Korean J Anesthesiol.
- 2017 Oct;70(5):500-510.
- doi: 10.4097/kjae.2017.70.5.500
Neuromuscular blockade plays an important role in the safe management of patient airways, surgical field improvement, and respiratory care. Rapid-sequence induction of anesthesia is indispensable to emergency surgery and obstetric... -
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- Imidacloprid inhibits IgE-mediated RBL-2H3 cell degranulation and passive cutaneous anaphylaxis
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Shi L, Zou L, Gao J, Xu H, Shi X, Chen H
- KMID: 2397020
- Asia Pac Allergy.
- 2016 Oct;6(4):236-244.
- doi: 10.5415/apallergy.2016.6.4.236
BACKGROUND: Imidacloprid has been commonly used as a pesticide for crop protection and acts as nicotinic acetylcholine receptor agonists. Little information about the relationship between imidacloprid and allergy is available. OBJECTIVE:... -
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- Differential Effects of Quercetin and Quercetin Glycosides on Human α7 Nicotinic Acetylcholine Receptor-Mediated Ion Currents
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Lee BH, Choi SH, Kim HJ, Jung SW, Hwang SH, Pyo MK, Rhim H, Kim HC, Kim HK, Lee SM, Nah SY
- KMID: 2351690
- Biomol Ther.
- 2016 Jul;24(4):410-417.
- doi: 10.4062/biomolther.2015.153
Quercetin is a flavonoid usually found in fruits and vegetables. Aside from its antioxidative effects, quercetin, like other flavonoids, has a various neuropharmacological actions. Quercetin-3-O-rhamnoside (Rham1), quercetin-3-O-rutinoside (Rutin), and quercetin-3-(2(G)-rhamnosylrutinoside... -
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- Cytisine, a Partial Agonist of α4β2 Nicotinic Acetylcholine Receptors, Reduced Unpredictable Chronic Mild Stress-Induced Depression-Like Behaviors
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Han J, Wang DS, Liu SB, Zhao MG
- KMID: 2164221
- Biomol Ther.
- 2016 May;24(3):291-297.
- doi: 10.4062/biomolther.2015.113
Cytisine (CYT), a partial agonist of α4β2-nicotinic receptors, has been used for antidepressant efficacy in several tests. Nicotinic receptors have been shown to be closely associated with depression. However, little... -
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- Nicotine in High Concentration Causes Contraction of Isolated Strips of Rabbit Corpus Cavernosum
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Nguyen HB, Lee SY, Park SH, Han JH, Lee MY, Myung SC
- KMID: 1791427
- Korean J Physiol Pharmacol.
- 2015 May;19(3):257-262.
- doi: 10.4196/kjpp.2015.19.3.257
It is well known that cigarette smoke can cause erectile dysfunction by affecting the penile vascular system. However, the exact effects of nicotine on the corpus cavernosum remains poorly understood.... -
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- Seven-Day Continuous Abstinence Rate from Smoking at 1, 2, or 3 Years after the Use of Varenicline
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Kim JS, Jang JY, Park EH, Lee JY, Gu KM, Jung JW, Choi JC, Shin JW, Park IW, Choi BW, Kim JY
- KMID: 2320600
- Tuberc Respir Dis.
- 2015 Apr;78(2):92-98.
- doi: 10.4046/trd.2015.78.2.92
BACKGROUND: Varenicline, a selective partial agonist/antagonist of the alpha4beta2 nicotinic receptor, has proven effectiveness for smoking cessation by several randomized, controlled trials. Because few studies have evaluated the long-term efficacy... -
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- Role of Nicotinic Acetylcholine Receptor alpha3 and alpha7 Subunits in Detrusor Overactivity Induced by Partial Bladder Outlet Obstruction in Rats
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Kim HS, Park WJ, Park EY, Koh JS, Hwang TK, Kim JC
- KMID: 2380821
- Int Neurourol J.
- 2015 Mar;19(1):12-18.
- doi: 10.5213/inj.2015.19.1.12
PURPOSE: To investigate the role of alpha3 and alpha7 nicotinic acetylcholine receptor subunits (nAChRs) in the bladder, using a rat model with detrusor overactivity induced by partial bladder outlet obstruction... -
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- Inhibitory Effects of Ginsenoside-Rb2 on Nicotinic Stimulation-Evoked Catecholamine Secretion
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Lim HJ, Lee HY, Lim DY
- KMID: 2285543
- Korean J Physiol Pharmacol.
- 2014 Oct;18(5):431-439.
- doi: 10.4196/kjpp.2014.18.5.431
The aim of the present study was to investigate whether ginsenoside-Rb2 (Rb2) can affect the secretion of catecholamines (CA) in the perfused model of the rat adrenal medulla. Rb2 (3~30... -
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- Genetic Association of CHRNB3 and CHRNA6 Gene Polymorphisms with Nicotine Dependence Syndrome Scale in Korean Population
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Won WY, Park B, Choi SW, Kim L, Kwon M, Kim JH, Lee CU, Shin HD, Kim DJ
- KMID: 2316352
- Psychiatry Investig.
- 2014 Jul;11(3):307-312.
OBJECTIVE: Cholinergic nicotinic receptor (CHRN) gene family has been known to mediate the highly additive effects of nicotine in the body, and implicated nicotine dependence (ND) and related phenotypes. Previous... -
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- Antidote for organophosphate insecticide poisoning: atropine and pralidoxime
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Chung SP, Roh HK
- KMID: 1783720
- J Korean Med Assoc.
- 2013 Dec;56(12):1057-1066.
- doi: 10.5124/jkma.2013.56.12.1057
Acute organophosphate (OP) poisoning produces cholinergic symptoms resulting from the inhibition of cholinesterase, and the overstimulation of muscarinic and nicotinic receptors in the synapses. The dominant clinical features of acute... -
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- The role of spinal adrenergic receptors on the antinociception of ginsenosides in a rat postoperative pain model
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Kim IJ, Park CH, Lee SH, Yoon MH
- KMID: 1828069
- Korean J Anesthesiol.
- 2013 Jul;65(1):55-60.
- doi: 10.4097/kjae.2013.65.1.55
BACKGROUND: The effect of spinal adrenergic and cholinergic receptors on the anti-nociceptive effect of intrathecal ginsenosides was determined in a rat postoperative pain model. METHODS: Catheters were placed into the intrathecal... -
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- Mechanism of Efferent Inhibition in Cochlear Hair Cell
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Im GJ
- KMID: 2277739
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2013 Feb;56(2):61-67.
- doi: 10.3342/kjorl-hns.2013.56.2.61
Efferent neurons release acetylcholine to inhibit sensory hair cells of the inner ear. The alpha9alpha10 nicotinic acetylcholine receptor (nAChR) mediates efferent inhibition of hair cell function within the auditory sensory... -
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- A Functional Polymorphism in the CHRNA3 Gene and Risk of Chronic Obstructive Pulmonary Disease in a Korean Population
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Lee JY, Yoo SS, Kang HG, Jin G, Bae EY, Choi YY, Choi JE, Jeon HS, Lee J, Lee SY, Cha SI, Kim CH, Park JY
- KMID: 2157978
- J Korean Med Sci.
- 2012 Dec;27(12):1536-1540.
- doi: 10.3346/jkms.2012.27.12.1536
A genome-wide association study has identified the 15q25 region as being associated with the risk of chronic obstructive pulmonary disease (COPD) in Caucasians. This study intended as a confirmatory assessment... -
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- Iptakalim Preferentially Decreases Nicotine-induced Hyperlocomotion in Phencyclidine-sensitized Rats: A Potential Dual Action against Nicotine Addiction and Psychosis
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Volf N, Hu G, Li M
- KMID: 1432539
- Clin Psychopharmacol Neurosci.
- 2012 Dec;10(3):168-179.
- doi: 10.9758/cpn.2012.10.3.168
OBJECTIVE: Iptakalim is a putative ATP-sensitive potassium (KATP) channel opener. It is also a novel nicotinic acetylcholine receptor (nAChR) blocker and can antagonize nicotine-induced increase in dopamine release in the... -
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- Role of Nicotinic Acetylcholine Receptor on Efferent Inhibition in Cochlear Hair Cell
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Im GJ
- KMID: 1430726
- Korean J Audiol.
- 2012 Dec;16(3):108-113.
- doi: 10.7874/kja.2012.16.3.108
The alpha9alpha10 nicotinic acetylcholine receptors (nAChRs) mediates efferent inhibition of hair cell function within the auditory sensory organ. Gating of the nAChRs leads to activation of calcium-dependent potassium channels to... -
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- Muscle Relaxants in Critically Ill Patients with Renal Disease
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Chon JY
- KMID: 2227961
- Korean J Crit Care Med.
- 2012 Aug;27(3):145-150.
- doi: 10.4266/kjccm.2012.27.3.145
Critical illness often results in renal dysfunction. Renal disease includes acid base imbalance, electrolyte shift and neuromuscular disturbances in critically ill patients, who are influenced by the pharmacodynamics and pharmacokinetics... -
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