Korean J Audiol.  2012 Dec;16(3):108-113. 10.7874/kja.2012.16.3.108.

Role of Nicotinic Acetylcholine Receptor on Efferent Inhibition in Cochlear Hair Cell

Affiliations
  • 1Department of Otolaryngology-Head and Neck Surgery, Korea University College of Medicine, Seoul, Korea. logopas@korea.ac.kr

Abstract

The alpha9alpha10 nicotinic acetylcholine receptors (nAChRs) mediates efferent inhibition of hair cell function within the auditory sensory organ. Gating of the nAChRs leads to activation of calcium-dependent potassium channels to hyperpolarize the hair cell. In efferent system, main calcium providers to SK channel are nAChR and synaptic cistern, which contribution to efferent inhibition is different between avian and mammalian species. Calcium permeation is more effective in nAChRs of mammalian cochlea than avian cochlea, and mammalian calcium permeability of nAChRs is about 3 times more than avian hair cell. Thus, mammalian nAChRs is a main component of efferent inhibition in cochlear hair cell system.

Keyword

Nicotinic receptor; Hair cell; Cochlea; Acetylcholine; Calcium

MeSH Terms

Acetylcholine
Calcium
Cochlea
Hair
Permeability
Potassium Channels, Calcium-Activated
Receptors, Nicotinic
Acetylcholine
Calcium
Potassium Channels, Calcium-Activated
Receptors, Nicotinic
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