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ROS Scavenger, Ebselen, Has No Preventive Effect in New Hearing Loss Model Using a Cholesterol-Chelating Agent

Lee MY, Kabara LL, Swiderski , Raphael Y, Duncan RK, Kim YH

BACKGROUND AND OBJECTIVES: The antioxidant ebselen will be able to limit or prevent the ototoxicity arising from 2-hydroxypropyl-β-cyclodextrin (HPβCD). Niemann-Pick Type C (NPC) disease is a disorder of lysosomal storage...
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Impact of Nicotine Exposure on Hair Cell Toxicity and Embryotoxicity During Zebrafish Development

Yoo MH, Rah YC, Park S, Koun S, Im GJ, Chae SW, Jung HH, Choi J

OBJECTIVES: Nicotine has various adverse effects including negative impacts associated with maternal exposure. In the current study, we examined nicotine-induced damage of hair cells and embryotoxicity during zebrafish development. METHODS: Zebrafish...
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Locacorten Vioform Ototoxicity Upon Guinea Pig Middle Ear Application

Woods O, Saliba I

BACKGROUND AND OBJECTIVES: Locacorten Vioform (Novartis UK) is frequently prescribed for otomycosis. Its component, Clioquinol, also has anti-bacterial properties. Up to this point, its ototoxic potential has not been evaluated....
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Differential Expression of Ca²⁺-buffering Protein Calretinin in Cochlear Afferent Fibers: A Possible Link to Vulnerability to Traumatic Noise

Sharma K, Seo YW, Yi E

The synaptic contacts of cochlear afferent fibers (CAFs) with inner hair cells (IHCs) are spatially segregated according to their firing properties. CAFs also exhibit spatially segregated vulnerabilities to noise. The...
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Inhibition of K⁺ outward currents by linopirdine in the cochlear outer hair cells of circling mice within the first postnatal week

Kang SW, Ahn JW, Ahn SC

Inhibition of K⁺ outward currents by linopirdine in the outer hair cells (OHCs) of circling mice (homozygous (cir/cir) mice), an animal model for human deafness (DFNB6 type), was investigated using...
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Hearing Improvement in A/J Mice via the Mouse Nerve Growth Factor

Gao L, Ge R, Xie G, Yao D, Li P, Wang O, Ma X, Han F

OBJECTIVES: To investigate the otoprotective effects of mouse nerve growth factor (mNGF) in A/J mice. METHODS: The mice at postnatal day 7 (P7) were randomly separated into a mNGF treated group...
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Atoh1 as a Coordinator of Sensory Hair Cell Development and Regeneration in the Cochlea

Lee S, Jeong HS, Cho HH

Cochlear sensory hair cells (HCs) are crucial for hearing as mechanoreceptors of the auditory systems. Clarification of transcriptional regulation for the cochlear sensory HC development is crucial for the improvement...
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Valuation of Transient Evoked Otoacoustic Emissions and Distortion Product Otoacoustic Emissions in Tinnitus Patients with Normal Hearing

Kim JT, Lee HS, Lee HR, Choi HS, Lee BD, Hwang K

BACKGROUND AND OBJECTIVES: This study aims to verify that one of the causes of tinnitus is the malfunction of outer hair cells and, on the basis of this, to investigate...
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MicroRNA-183 Family in Inner Ear: Hair Cell Development and Deafness

Mahmoodian sani MR, Hashemzadeh-Chaleshtori M, Saidijam M, Jami MS, Ghasemi-Dehkordi P, Saidijam M, Jami MS

miRNAs are essential factors of an extensively conserved post-transcriptional process controlling gene expression at mRNA level. Varoius biological processes such as growth and differentiation are regulated by miRNAs. Web of...
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The Hyperactivity of Efferent Auditory System in Patients with Schizophrenia: A Transient Evoked Otoacoustic Emissions Study

Abdul Wahab NA, Wahab S, Abdul Rahman AH, Sidek D, Zakaria MN

OBJECTIVE: Electrophysiological studies, which are mostly focused on afferent pathway, have proven that auditory processing deficits exist in patients with schizophrenia. Nevertheless, reports on the suppressive effect of efferent auditory...
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Stem Cell Therapy for Sensorineural Hearing Loss, Still Alive?

Park YH

In mammals, the auditory system, which includes the cochlea, has a very complex structure harboring many types of cells performing different functions. Among these cells are the auditory hair cells...
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Characteristics of K+ Outward Currents in the Cochlear Outer Hair Cells of Circling Mice within the First Postnatal Week

Ahn JW, Kang SW, Ahn SC

K+ outward currents in the outer hair cells (OHCs) of circling mice (homozygous (cir/cir) mice), an animal model for human deafness (DFNB6 type), were investigated using a whole cell patch...
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Neural-Induced Human Mesenchymal Stem Cells Promote Cochlear Cell Regeneration in Deaf Guinea Pigs

Jang S, Cho HH, Kim SH, Lee KH, Jun JY, Park JS, Jeong HS, Cho YB

OBJECTIVES: In mammals, cochlear hair cell loss is irreversible and may result in a permanent sensorineural hearing loss. Secondary to this hair cell loss, a progressive loss of spiral ganglion...
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Noise-Induced Hearing Loss

Shim HJ

Noise-induced hearing loss (NIHL) is the second most common cause of permanent hearing impairment after age-related hearing loss. NIHL is influenced by environmental and genetic factors and the effects of...
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Role of histone deacetylase activity in the developing lateral line neuromast of zebrafish larvae

He Y, Mei H, Yu H, Sun S, Ni W, Li H

Histone deacetylases are involved in many biological processes and have roles in regulating cell behaviors such as cell cycle entry, cell proliferation and apoptosis. However, the effect of histone deacetylases...
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The Protective Effect of Epigallocatechin-3-Gallate Against Gentamicin Vestibular Ototoxicity in Type I Vestibular Hair Cell of Guinea Pig

Choi YH, Lee SS, Moon SJ, Ahn BH, Kim NG, Jeong HS, Park JS, Cho HH, Cho YB

BACKGROUND AND OBJECTIVES: Gentamicin (GM) is well known for its vestibulotoxicity. There have been many reports about vestibulotoxicity, however, its mechanism is still unclear. So far, it is known that...
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Protective Effect of Hexane and Ethanol Extract of Piper Longum L. on Gentamicin-Induced Hair Cell Loss in Neonatal Cultures

Yadav MK, Choi J, Song JJ

  • KMID: 2278396
  • Clin Exp Otorhinolaryngol.
  • 2014 Mar;7(1):13-18.
OBJECTIVES: Gentamicin (GM) is a commonly used aminoglycoside antibiotic that generates free oxygen radicals within the inner ear, which can cause vestibulo-cochlear toxicity and permanent damage to the sensory hair...
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Temperature Enhances Activation and Inactivation Kinetics of Potassium Currents in Inner Hair Cells Isolated from Guinea-Pig Cochlea

Kimitsuki , Komune S

  • KMID: 2468434
  • Clin Exp Otorhinolaryngol.
  • 2013 Sep;6(3):140-145.
OBJECTIVES: Until recently, most patch-clamp recordings in inner hair cells (IHCs) have been performed at room temperature. The results acquired at room temperature should be corrected if they are to...
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Changes of Cochlear Nerve Terminals after Temporary Noise-Induced Hearing Loss

Seo JK, Lim HW, Park HJ, Pak JH, Chung JW

BACKGROUND AND OBJECTIVES: Overexposure to intense sound can cause temporary or permanent hearing loss. Post-exposure recovery of thresholds has been assumed to indicate reversal of damage to the inner ear...
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Different uptake of gentamicin through TRPV1 and TRPV4 channels determines cochlear hair cell vulnerability

Lee JH, Park C, Kim SJ, Kim HJ, Oh GS, Shen A, So HS, Park R

  • KMID: 2154231
  • Exp Mol Med.
  • 2013 Mar;45(3):e12.
Hair cells at the base of the cochlea appear to be more susceptible to damage by the aminoglycoside gentamicin than those at the apex. However, the mechanism of base-to-apex gradient...
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