Korean J Anesthesiol.
2013 Jan;64(1):3-5. 10.4097/kjae.2013.64.1.3.
In the hour of Sugammadex
- Affiliations
-
- 1Department of Anesthesiology and Pain Medicine, The Catholic University of Korea School of Medicine, Seoul, Korea. anestha@catholic.ac.kr
- KMID: 2236226
- DOI: http://doi.org/10.4097/kjae.2013.64.1.3
Abstract
- Sugammadex is a modified gamma-cyclodextrin which is showing favorable outcomes regarding reversal of neuromuscular blockade, especially by rocuronium. It is designed to encapsulate rocuronium and being considered a new class of drugs as selective relaxant binding agents. It has given countless benefits to the patients at risk of incomplete or delayed recovery after neuromuscular block and has renown for another milestone in anesthesia practice. Recurrence of neuromuscular block has not been reported to be associated with the provided doses of sugammadex that are adequate for selected for reversal. Acceptable profiles are brought to light telling safety of sugammadex. However, some questions related to the twitch characteristics those resembled succinylcholine when reversal, the application for rocuronium anaphylaxis, and the hypersensitivity or anaphylaxis to sugammadex remain and are need of further investigation. It is imperative that potential problems that we need attention may include the patient's history of pulmonary disease and allergic disease for using sugammadex.
