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Effect of patient decision aids on choice between sugammadex and neostigmine in surgeries under general anesthesia: a multicenter randomized controlled trial

Wang LK, Lin YT, Chen JT, Lan W, Hung KC, Chen JY, Liu KJ, Yen YC, Chou YY, Cherng YG, Tam KW

Background: Shared decision making using patient decision aids (PtDAs) was established over a decade ago, but few studies have evaluated its efficacy in Asian countries. We therefore evaluated the application...
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What we need to know and do on sugammadex usage in pregnant and lactating women and those on hormonal contraceptives

Do W, Cho AR

Sugammadex is a chemically modified γ-cyclodextrin that is used as a selective reversal agent for steroidal neuromuscular blockade. The use of sugammadex has greatly increased globally; however, little is known...
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Evaluation of the effects of bupivacaine combined with sugammadex on the duration of the nociceptive blockade in sciatic nerve blocks: a controlled, double-blind animal study

Tasargol O, Darbaz I, Ergene O, Zabitler F, Deniz A, Kose SG, Kose HC, Tulgar S

Background: Animal and other experimental studies have demonstrated increased block time and quality when α- and β-cyclodextrin drugs are combined with local anesthetics. However, to our knowledge, no study has...
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Cardiac arrest due to coronary vasospasm after sugammadex administration -a case report-

Boo KY, Park SH, Park SK, Na C, Kim HJ

Backgroud: Sugammadex is a widely used medication for the reversal of aminosteroid neuromuscular blockades. Although sugammadex is generally regarded to be safe, concerns about the risk of serious complications have...
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Sugammadex administration in patients with end-stage renal disease: a narrative review with recommendations

Oh SK, Lim BG

Due to unknown safety concerns, sugammadex should not be administered to patients withend-stage renal disease (ESRD). However, because the supply of benzylisoquinolinium-typeneuromuscular blocking agents (NMBAs) has been discontinued, rocuronium is...
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Does the Use of Rocuronium-Sugammadex Instead of Succinylcholine in Electroconvulsive Therapy Affect Seizure Duration?

Oflezer C, Atay Ö, Kaşdoğan ZE, Özakay G, İpekçioğlu D, Bahadır H

Objective We compared retrospectively the seizure variables of electroconvulsive therapy (ECT) patients after administration of rocuronium-sugammadex or succinylcholine as a muscle relaxant with propofol anesthesia. Methods The sample comprised 134 ECT...
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Postoperative mortality in patients with end-stage renal disease according to the use of sugammadex: a single-center retrospective propensity score matched study

Song S, Cho HB, Park SY, Koo WM, Choi SJ, Yoon S, Park S, Yoo JH, Kim MG, Chung JW, Kim SH

excretion. There are restrictions on the use of sugammadex in patients with severe renal impairment. A paucity of data supports the clinical safety of sugammadex in patients with renal impairment....
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Choice of neuromuscular block reversal agent to reduce postoperative pulmonary complications

Cho SA, Sung TY

The definition of postoperative pulmonary complications (PPCs) is inconsistent in literature; however, PPCs include pulmonary abnormalities that adversely affect patient outcomes, such as respiratory failure, atelectasis, pneumonia, pleural effusion, and...
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Adverse events of sugammadex that occurred in a Korean population

Han W, Lee JM, Park DH, Lee CA, Jeong CY, Yang HS

Background: With increasing use, the incidence of adverse events associated with sugammadex, a neuromuscular blockade reverser, is increasing. This study aimed to identify and analyze cases of adverse events caused...
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Effects of hydrocortisone-presensitized sugammadex on recovery from neuromuscular blockade induced by rocuronium: a rodent in vivo study

Choi HR, Yang HS, Choi JM, Park C, In J, Kim YB

Background: Sugammadex is a specific antagonist of aminosteroidal neuromuscular blocking agents with 1:1 binding to guest molecules. Sugammadex can also bind to other drugs having a steroid component in its...
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The use of sugammadex in an infant with prolonged neuromuscular blockade - A case report -

Kim H, Cho J, Lee S, Lim Y, Yoo B

Background: Residual neuromuscular blockade (RNMB) is a frequent event after general anesthesia, which can lead to serious complications, such as upper airway obstruction. Sugammadex is useful in reversing RNMB. However,...
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Successful Anesthetic Management of Myotonic Dystrophy Type I Using Sugammadex: A Case Report

Kim S, Chun HR, Chung J

Myotonic dystrophy (DM) is an uncommon inherited disease. Anesthesia for DM patients is tough due to its potency of cardiogenic and pulmonary problems, but a series of studies have shown...
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Comparison of postoperative pulmonary complications between sugammadex and neostigmine in lung cancer patients undergoing video-assisted thoracoscopic lobectomy: a prospective double-blinded randomized trial

Lee TY, Jeong SY, Jeong JH, Kim JH, Choi SR

Background: Reversal of neuromuscular blockade (NMB) at the end of surgery is important for reducing postoperative residual NMB; this is associated with an increased risk of postoperative pulmonary complications (PPCs)....
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Treatment of rocuronium-induced anaphylaxis using sugammadex - A case report -

Kim SM, Oh Sh, Ryu SA

Background: Perioperative anaphylaxis is a life-threatening clinical condition characterized by severe respiratory and cardiovascular manifestations. Neuromuscular blocking agents are the most common cause of anaphylaxis during anesthesia. Case: We report...
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Anaphylaxis induced by sugammadex and sugammadex-rocuronium complex -a case report-

Choi SC, Han S, Kwak J, Lee JY

Background: In sugammadex-induced anaphylaxis, sugammadex and/or sugammadex-rocuronium complex have possible allergenic epitope. Case: We report a case of sugammadex-induced anaphylaxis during general anesthesia in a 60-year-old male undergoing...
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Advantages and pitfalls of clinical application of sugammadex

Lee HY, Jung KT

Sugammadex, a modified γ-cyclodextrin, is one of the drugs focused on in the anesthetic field because it provides rapid and complete reversal from neuromuscular blockade (NMB) by encapsulating rocuronium. Its...
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Effects of different sugammadex doses on the train of four ratio recovery progression during rocuronium induced neuromuscular blockade in the rat phrenic nerve hemidiaphragm

Kim YB, Choi JM, Chang YJ, Choi HR, In J, Yang HS

Background: In this study, we used an ex-vivo model to investigate the recovery pattern of both the train-of-four (TOF) ratio and first twitch tension of TOF (T1), and determined their...
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The effect of atropine in preventing catheter-related pain and discomfort in patients undergoing transurethral resection due to bladder tumor; prospective randomized, controlled study

Şahiner Y, Yağan , Ekici AA, Ekici M, Demir E

Background: Catheter-related bladder discomfort (CRBD) has been observed in many patients undergoing a urethral catheterization. CRBD may be so severe that the patients require additional analgesics. Muscarinic receptors are involved...
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Neuromuscular blockade reversal with sugammadex versus pyridostigmine/ glycopyrrolate in laparoscopic cholecystectomy: a randomized trial of effects on postoperative gastrointestinal motility

An J, Noh H, Kim E, Lee J, Woo K, Kim H

Background: Acetylcholinesterase inhibitors (e.g., pyridostigmine bromide) are used for neuromuscular blockade (NMB) reversal in patients undergoing surgery under general anesthesia (GA). Concurrent use of anticholinergic agents (e.g., glycopyrrolate) decreases cholinergic...
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Evaluation of the Toxicity of Sugammadex in Zebrafish Larvae

Kim WY, Kim YH, Lee JY, Kim JH, Min TJ

BACKGROUND: Sugammadex is a new neuromuscular blockade reversal agent. Recently, it has been used in patients under general anesthesia. However, sugammadex could be toxic to fetuses and pediatric patients under...
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