- Neuromuscular blockade management in patients with COVID-19
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Chaves-Cardona H, Hernandez-Torres V, Kiley S, Renew J
- KMID: 2520721
- Korean J Anesthesiol.
- 2021 Aug;74(4):285-292.
- doi: 10.4097/kja.21106
This narrative review evaluates the evidence for using neuromuscular blocking agents (NMBA) in patients being treated for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). While large prospective randomized-controlled trials (RCTs)... -
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- Comparison of postoperative pulmonary complications between sugammadex and neostigmine in lung cancer patients undergoing video-assisted thoracoscopic lobectomy: a prospective double-blinded randomized trial
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Lee TY, Jeong SY, Jeong JH, Kim JH, Choi SR
- KMID: 2512283
- Anesth Pain Med.
- 2021 Jan;16(1):60-67.
- doi: 10.17085/apm.20056
Background: Reversal of neuromuscular blockade (NMB) at the end of surgery is important for reducing postoperative residual NMB; this is associated with an increased risk of postoperative pulmonary complications (PPCs).... -
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- Advantages and pitfalls of clinical application of sugammadex
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Lee HY, Jung KT
- KMID: 2504886
- Anesth Pain Med.
- 2020 Jul;15(3):259-268.
- doi: 10.17085/apm.19099
Sugammadex, a modified γ-cyclodextrin, is one of the drugs focused on in the anesthetic field because it provides rapid and complete reversal from neuromuscular blockade (NMB) by encapsulating rocuronium. Its... -
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- Effects of different sugammadex doses on the train of four ratio recovery progression during rocuronium induced neuromuscular blockade in the rat phrenic nerve hemidiaphragm
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Kim YB, Choi JM, Chang YJ, Choi HR, In J, Yang HS
- KMID: 2503128
- Korean J Anesthesiol.
- 2020 Jun;73(3):239-246.
- doi: 10.4097/kja.19278
Background: In this study, we used an ex-vivo model to investigate the recovery pattern of both the train-of-four (TOF) ratio and first twitch tension of TOF (T1), and determined their... -
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- Effect of intraoperative neuromonitoring on efficacy and safety using sugammadex in thyroid surgery: randomized clinical trial
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Gunes ME, Dural AC, Akarsu C, Guzey D, Sahbaz NA, Tulubas EK, Bulut S, Donmez T
- KMID: 2464783
- Ann Surg Treat Res.
- 2019 Dec;97(6):282-290.
- doi: 10.4174/astr.2019.97.6.282
PURPOSE: The use of nondepolarizing neuromuscular blocking agents (NMBAs) may affect intraoperative neuromonitoring (IONM) during anesthesia used during thyroid and parathyroid surgery. METHODS: The use of sugammadex was evaluated in a... -
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- Sugammadex associated profound bradycardia and sustained hypotension in patient with the slow recovery of neuromuscular blockade: A case report
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Choi YJ, Park JW, Kim SH, Jung KT
- KMID: 2454815
- Anesth Pain Med.
- 2019 Jul;14(3):299-304.
- doi: 10.17085/apm.2019.14.3.299
BACKGROUND: New complications associated with sugammadex have been increased since its widespread use. We report a case of an 80-year-old male who experienced profound bradycardia and sustained hypotension after administration... -
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- Effect of levetiracetam on rocuronium duration in patients undergoing cerebrovascular surgery
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Jeon YJ, Kim MH
- KMID: 2436000
- Anesth Pain Med.
- 2018 Oct;13(4):409-414.
- doi: 10.17085/apm.2018.13.4.409
BACKGROUND: It has long been held that antiepileptics reduce the duration of action, and increase the requirement for, neuromuscular blocking agents. However, levetiracetam, a relatively novel antiepileptic agent, possesses different... -
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- The effect of magnesium sulfate concentration on the effective concentration of rocuronium, and sugammadex-mediated reversal, in isolated left phrenic nerve hemi-diaphragm preparations from the rat
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Cho CK, Sung TY, Choi SJ, Choi HR, Kim YB, Lee JU, Yang HS
- KMID: 2424684
- Korean J Anesthesiol.
- 2018 Oct;71(5):401-406.
- doi: 10.4097/kja.d.17.27150
BACKGROUND: Perioperative magnesium sulfate (MgSO4) is used for analgesic, anti-arrhythmic, and obstetric purposes. The effects of MgSO4 on the neuromuscular blockade (NMB) induced by rocuronium, and the sugammadex reversal thereof,... -
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- Initial experience with the unrestricted introduction of sugammadex at a large academic medical center: a retrospective observational study examining postoperative mechanical ventilation and efficiency outcomes
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O'Reilly-Shah VN, Lynde GC, Mitchell M, Maffeo CL, Jabaley CS, Wolf FA
- KMID: 2424681
- Korean J Anesthesiol.
- 2018 Oct;71(5):374-385.
- doi: 10.4097/kja.d.18.00063
BACKGROUND: Sugammadex rapidly reverses deep neuromuscular blockade, but owing to cost, questions remain about its optimal utilization. After the unrestricted introduction of sugammadex at Emory University Hospital, we hypothesized that... -
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- Anesthetic considerations in a child with Sotos syndrome: A case report
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Chung JY, Kim G, Park JH, Choi HK, Park BH, Choi MY, Kim JS
- KMID: 2388839
- Anesth Pain Med.
- 2017 Jul;12(3):240-242.
- doi: 10.17085/apm.2017.12.3.240
Sotos syndrome is a rare sporadic genetic disorder characterized by pathognomonic facial features, motor developmental delay induced by hypotonia, learning difficulties, and cardiac and renal anomalies. This report describes the... -
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- Comparing the effects of vecuronium and cisatracurium on electrophysiologic monitoring during neurosurgery: a randomized controlled study
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Chung YH, Chung IS, Kim MH, Shin J, Park J, Lee JJ
- KMID: 2388834
- Anesth Pain Med.
- 2017 Jul;12(3):213-219.
- doi: 10.17085/apm.2017.12.3.213
BACKGROUND: The differences between neuromuscular blocking (NMB) drugs on the efficacy of intraoperative motor-evoked potential (MEP) monitoring have not been established through clinical study. We compared the effects of vecuronium... -
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- Influence of acute normovolemic hemodilution on the potency and time course of action of rocuronium in rabbits
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Lee JH, Kim KS, Kim TY, Oh YN, Lee W
- KMID: 2344931
- Anesth Pain Med.
- 2016 Jul;11(3):273-279.
- doi: 10.17085/apm.2016.11.3.273
BACKGROUND: We performed this study to evaluate the potency and time course of rocuronium-induced neuromuscular block following moderate or severe acute normovolemic hemodilution (ANH) in rabbits. METHODS: Forty five rabbits were... -
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- The combination of sugammadex and neostigmine can reduce the dosage of sugammadex during recovery from the moderate neuromuscular blockade
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Cheong SH, Ki S, Lee J, Lee JH, Kim MH, Hur D, Cho K, Lim SH, Lee KM, Kim YJ, Lee W
- KMID: 2237304
- Korean J Anesthesiol.
- 2015 Dec;68(6):547-555.
- doi: 10.4097/kjae.2015.68.6.547
BACKGROUND: Sugammadex is a novel neuromuscular reversal agent, but its associated hypersensitivity reaction and high cost have been obstacles to its widespread use. In the interest of reducing the necessary... -
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- Comparison of etomidate and propofol on intubating conditions and the onset time associated with cisatracurium administration
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Ko YK, Kim YH, Park SI, Chung WS, Noh C, Lee JU
- KMID: 2236152
- Korean J Anesthesiol.
- 2015 Apr;68(2):136-140.
- doi: 10.4097/kjae.2015.68.2.136
BACKGROUND: This study compared intubating conditions and the onset time associated with administration of cisatracurium, a nondepolarizing neuromuscular blocker with a relatively slow onset, according to prior injection of one... -
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- The effect of high concentration of magnesium with ropivacaine, gentamicin, rocuronium, and their combination on neuromuscular blockade
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Rhee WJ, Lee SY, Lee JH, Choi SR, Lee SC, Lee JH, Lee SI
- KMID: 2236190
- Korean J Anesthesiol.
- 2015 Feb;68(1):50-61.
- doi: 10.4097/kjae.2015.68.1.50
BACKGROUND: Magnesium, ropivacaine, gentamicin, and rocuronium block neuromuscular (NM) transmission by different mechanisms. Therefore, concurrent administration of these agents may induce prolonged muscle paralysis via synergistic interaction. This study investigated... -
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- Effect of muscle relaxation on the oxygenation of human skeletal muscle: a prospective in-vivo experiment using an isolated forearm technique
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Rhee KY, Kim TY, Oh IS, Lee SJ, Ledowski T
- KMID: 2236183
- Korean J Anesthesiol.
- 2015 Feb;68(1):13-16.
- doi: 10.4097/kjae.2015.68.1.13
BACKGROUND: Total oxygen consumption has been found to be reduced under deep neuromuscular blockade due to a lower rate of metabolism of skeletal muscles. However, the magnitude of this effect... -
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- Effect of pneumoperitoneum on the recovery from intense neuromuscular blockade by rocuronium in healthy patients undergoing laparoscopic surgery
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Kim HS, Lee DC, Lee MG, Son WR, Kim YB
- KMID: 2236201
- Korean J Anesthesiol.
- 2014 Jul;67(1):20-25.
- doi: 10.4097/kjae.2014.67.1.20
BACKGROUND: This study investigated the effect of pneumoperitoneum on the recovery from intense neuromuscular blockade by rocuronium in healthy patients undergoing laparoscopic abdominal surgery. METHODS: Thirty adult patients undergoing laparoscopic abdominal... -
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- Optimal precurarizing dose of rocuronium to decrease fasciculation and myalgia following succinylcholine administration
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Kim KN, Kim KS, Choi HI, Jeong JS, Lee HJ
- KMID: 2237950
- Korean J Anesthesiol.
- 2014 Jun;66(6):451-456.
- doi: 10.4097/kjae.2014.66.6.451
BACKGROUND: Succinylcholine commonly produces frequent adverse effects, including muscle fasciculation and myalgia. The current study identified the optimal dose of rocuronium to prevent succinylcholine-induced fasciculation and myalgia and evaluated the... -
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- Sugammadex versus neostigmine reversal of moderate rocuronium-induced neuromuscular blockade in Korean patients
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Woo T, Kim KS, Shim YH, Kim MK, Yoon SM, Lim YJ, Yang HS, Phiri P, Chon JY
- KMID: 2092375
- Korean J Anesthesiol.
- 2013 Dec;65(6):501-507.
- doi: 10.4097/kjae.2013.65.6.501
BACKGROUND: Rapid and complete reversal of neuromuscular blockade (NMB) is desirable at the end of surgery. Sugammadex reverses rocuronium-induced NMB by encapsulation. It is well tolerated in Caucasian patients, providing... -
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- Sugammadex: clinical development and practical use
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Fuchs-Buder T, Meistelman C, Raft J
- KMID: 2092374
- Korean J Anesthesiol.
- 2013 Dec;65(6):495-500.
- doi: 10.4097/kjae.2013.65.6.495
Sugammadex is belonging to a new class of drugs: the selective relaxant binding agents. Sugammadex can reverse residual paralysis by encapsulating free circulating non depolarizing muscle relaxants. The mains advantages... -
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