Korean J Anesthesiol.  2020 Aug;73(4):342-346. 10.4097/kja.19344.

Anaphylaxis induced by sugammadex and sugammadex-rocuronium complex -a case report-

• Choi SC
• Han S
• Kwak J
• Lee JY

• KMID: 2505113
• DOI: http://doi.org/10.4097/kja.19344

Abstract

Background
In sugammadex-induced anaphylaxis, sugammadex and/or sugammadex-rocuronium complex have possible allergenic epitope. Case: We report a case of sugammadex-induced anaphylaxis during general anesthesia in a 60-year-old male undergoing orthopedic hand surgery, manifesting as profound hypotension and urticaria. The timing of onset was closely associated with sugammadex administration. The patient recovered after extensive therapy including fluid, epinephrine, other vasopressors, steroid, and antihistamine administration. By intradermal skin test which was done at four weeks after anaphylaxis, we confirmed positive reactions to both sugammadex and sugammadex-rocuronium complex.
Conclusions
This is a rare case of sugammadex-induced anaphylaxis that both sugammadex and sugammadex-rocuronium complex were confirmed as allergenic epitopes.

Keyword

Anaphylaxis; General anesthesia; Hypotension; Rocuronium; Skin test; Sugammadex; Urticaria