The Effect of Interferon-alpha and bFGF on the Proliferation of Cultured Leiomyoma and Myometrial Cells

Lee, B S; Park, J S; Kim, J Y; Bae, S W; Park, K H; Cho, D J; Lee, K; Kim, J W; Song, C H

Abstract

Leiomyomas, which are the commonest pelvic tumors in women, are originated from myometrial cells. Although the exact initial pathophysiologic event of the leiomyoma is not known, recent evidences suggested that the effects of sex steroid hormones in the process of tumor growth are mediated by local production of growth factors including epidermal growth factor (EGF), insulin-like growth factor-I (IGF-I) and insulin-like growth factor-II (IGF-II). If we look at the effects of other cytokines, it was suggested that basic fibroblast growth factor (bFGF) may stimulate the proliferation of myometrial and leiomyomas cells. And it was reported that interferon-alpha inhibit the action of bFGF Therefore, we examined the effect of bFGF and interferon-alpha on the proliferation of leiomyoma and myometrial cells. bFGF stimulated the myometrial and leiomyoma cells significantly at the concentration of 1ng/ml (p<0.05) and 5ng/ml (p<0.05). However, Interferon-alpha inhibited the cell proliferation of myometrial and leiomyoma cells significantly at the concentration of 100U/m10<0.05) and 1000U/m1 (p<0.05). And the stimulated effects of bFGF with the various concentration on the myometrial and leiomyoma cells ware inhibited by interferon-alpha with 100U/m1. Therefore, we concluded that bFGF may stimulate the myometrial and leiomyoma cell proliferation and interferon-alpha may inhibit the myometrial and leiomyoma cell proliferation through blocking the effect of basic fibroblast growth factor.

The Effect of Interferon-alpha and bFGF on the Proliferation of Cultured Leiomyoma and Myometrial Cells

Abstract

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