Kidney Res Clin Pract.
2014 Mar;33(1):3-8.
Treatment of phosphate retention: The earlier the better?
- Affiliations
-
- 1Klinikum Coburg GmbH, Department of Nephrology, Coburg, Germany. patrick.biggar@t-online.de
- 2Princess Margaret Hospital, Kowloon West Cluster Hospital Authority, Kowloon, Hong Kong SAR, China.
Abstract
- Over the last 15 years, our knowledge and understanding of the underlying mechanisms involved in the regulation of calcium and phosphate homeostasis in chronic kidney disease have advanced dramatically. Contrary to general opinion in the 20th century that moderate hypercalcemia and hyperphosphatemia were acceptable in treating secondary hyperparathyroidism, the calcium and phosphate load is increasingly perceived to be a major trigger of vascular and soft tissue calcification. The current treatment options are discussed in view of historical developments and the expectations of the foreseeable future, focusing on the early treatment of hyperphosphatemia. At present, we lack in disputable evidence that active intervention using currently available drugs is of benefit to patients in chronic kidney disease stages 3 and 4.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Comparison of the retention of the full veneer casted gold crowns with varying convergence angle, crown length and dental cements
- A literature review on cementation of implant prosthesis
- THE RETRIEVABILITY OF CEMENTATION TYPE IMPLANT ABUTMENT BY SURFACE TREATMENTS AND TYPES OF CEMENTS
- A Randomized Prospective Trial Comparing Oral Sodium Phosphate with Magnesium citrate in Preparing of Patients for Double Contrast Barium Enema
- A clinical study on the retention of maxillary complete denture with different denture base materials
