J Korean Ophthalmol Soc.  2007 May;48(5):630-636.

Changes of Tear Parameters after Using Cyclosporine A in Dry Eye with Thyroid Ophthalmopahty

• Oh HJ
• You IC
• Yoon KC

Abstract

PURPOSE: This study was performed to evaluate the changes of tear film and ocular surface after using cyclosporine A in patients with thyroid-associated ophthalmopathy accompanied by dry eye.
METHODS
Corneal sensitivity test (CST), tear break-up time (BUT), basal tear secretion test (BST), fluorescein staining (FS), tear clearance rate (TCR), and conjunctival impression cytology were evaluated in 28eyes of 28 patients with thyroid-associated ophthalmopathy accompanied by dry eye before and after using 0.1 cyclosporine A.
RESULTS
CST (P=0.03), BUT (P<0.01), and BST (P=0.01) were shown significant improvements after 3 month treatment with topical 0.1% cyclosporine A. There are also shown improvments of impression cytologic findings, reduction of the degree of conjunctival squamous cell metaplasia (P=0.02) and increment of the density of goblet cell (P=0.04) after 3 month treatment. But TCR and FS were shown no significant changes after treatment.
CONCLUSIONS
The improvement of parameters of tear films and ocular surface suggest the treatment with 0.1% cyclosporine A for dry eye in thyroid ophthalmopathy was effective.

Keyword

Cyclosporine A; Ocular surface; Tear film; Thyroid-associated ophthalmopathy

MeSH Terms

Cyclosporine*
Fluorescein
Goblet Cells
Graves Ophthalmopathy
Humans
Metaplasia
Tears*
Thyroid Gland*
Cyclosporine
Fluorescein