J Korean Pediatr Soc.  2001 Aug;44(8):971-975.

A Case of Graves Disease with Kyphosis by Osteoporosis

• Na YW
• Lee KH
• Yoo KH
• Hong YS
• Lee JW
• Kim SK

Abstract

Graves disease is the most common clinical feature of hyperthyroidism in childhood. Clinical manifestations include emotional lability, hyperactivity, tremor, excessive sweating, exophthalmos and weight loss. In Graves disease, osteoporosis could occur because of a disturbance of mineral homeostasis which rarely develops from reduced calcium absorption of the gastrointestinal tract and increased urinary calcium excretion related to an increased bone resorption. We report a case of Graves disease with spinal deformity caused by osteoporosis in a 12-year-old female who was presented with back pain, anterior neck mass and kyphosis. Laboratory findings revealed hyperthyroidsm, hypercalciuria in 24-hour urine and normal serum parathyroid hormone. On radiologic examination, multiple osteoporosis and a spinal compression fracture were observed. The bone mineral density was decreased at the hip and lumbar spine on the bone densitometry. After initiating antithyroid drug, calcitonin and vitamin D, she returned to a euthyroid state and her back pain was improved. Bone density was also increased one year later.

Keyword

Graves disease; Kyphosis; Osteoporosis

MeSH Terms

Absorption
Back Pain
Bone Density
Bone Resorption
Calcitonin
Calcium
Child
Congenital Abnormalities
Densitometry
Exophthalmos
Female
Fractures, Compression
Gastrointestinal Tract
Graves Disease*
Hip
Homeostasis
Humans
Hypercalciuria
Hyperthyroidism
Kyphosis*
Neck
Osteoporosis*
Parathyroid Hormone
Spine
Sweat
Sweating
Tremor
Vitamin D
Weight Loss
Calcitonin
Calcium
Parathyroid Hormone
Vitamin D