J Korean Soc Endocrinol.  2003 Aug;18(4):426-432.

A Case of Atypical McCune-Albright Syndrome Associated with Hyperthyroidism and Hypersecretion of Growth Hormone

• You MB
• Kang KH
• Lee BS
• Chae EH
• Kim MC
• Jung JI
• Park SH
• Lee HJ
• Jung ST

Abstract

McCune-Albright syndrome is characterized by polyostotic fibrous dysplasia, Caf -au-lait pigmentation and precocious puberty or other endocrinopathy. It can be caused by substitution of His, Cys or Gly for Arg 201st amino acid of the Gs protein subunit. The case of a 32-year-old woman, with atypical McCune-Albright syndrome, is reported. She had no skin lesion or precocity puberty. The polyostotic fibrous dysplasia was examined by a simple radiological image and whole body scan. She developed hyperthyroidism, with a multinodular toxic goiter. No thyroid related autoantibodies were detected. The cause of hyperthyroidism was thought to be a non- autoimmune thyroid hyperfunction. The level of growth hormone was not suppressed by oral glucose load. After a bromocriptine suppression test, the level of growth hormone decreased. There was no mass in the pituitary gland on a sellar MRI. A case of atypical McCune-Albright syndrome, including hyperthyroidism and hypersecretion of growth hormone, is reported.

MeSH Terms

Adolescent
Adult
Autoantibodies
Bromocriptine
Female
Fibrous Dysplasia, Polyostotic*
Glucose
Goiter
Growth Hormone*
Humans
Hyperthyroidism*
Magnetic Resonance Imaging
Pigmentation
Pituitary Gland
Protein Subunits
Puberty
Puberty, Precocious
Skin
Thyroid Gland
Whole Body Imaging
Autoantibodies
Bromocriptine
Glucose
Growth Hormone
Protein Subunits