J Korean Soc Endocrinol.  2003 Feb;18(1):24-31.

Adequate Duration of Medical Therapy for Koreans with Graves' Disease

• Lee HS
• Lee DH
• Chung HS
• Lee JW
• Kim JE
• Shin SS
• Chung YS
• Lee KW
• Kim HM

Abstract

BACKGROUND: Graves' disease is an organ specific autoimmune disease. Three kinds of therapeutic modalities(antithyroid drugs, ablation with radioactive iodine and subtotal thyroidectomy) are frequently performed for the management of this disease. The most popular therapeutic policy for the disease in Korea is antithyroid treatment. We analysed and compared the remission rates of all three modalities for Graves' disease, and evaluated the antithyroid modality to determine the correct duration of treatment.
SUBJECTS AND METHODS
The medical records of 205 patients with Graves' disease were reviewed. For the evaluation of the antithyroid modality medical treatment, antithyroid drugs were administered for more than 1 year. The prognostic factors associated with remission were analysed by means of an ROC curve.
RESULTS
1) Of the 205 patients, proportions that received medical therapy, subtotal thyroidectomy and radioiodine therapy were 83.0, 14.1 and 2.9%, respectively. 2) The remission rates of the medical therapy, surgery and radioiodine therapy were 60.0, 96.5 and 83.0%, respectively. 3) The remission rate of the medical therapy was associated with the duration of medication and TBII activity. The determined proper duration for the antithyroid treatment was 26 months from the ROC curve analysis.
CONCLUSION
The above results suggest that the proper duration of antithyroid treatment for Graves' disease is 26 months, after which time the subtotal thyroidectomy or radioiodine therapy should be considered if the disease has not remitted.

MeSH Terms

Antithyroid Agents
Autoimmune Diseases
Graves Disease*
Humans
Iodine
Korea
Medical Records
ROC Curve
Thyroidectomy
Antithyroid Agents
Iodine