J Korean Soc Pediatr Endocrinol.  1998 May;3(1):68-72.

Serum Neopterin Concentration in Children with Graves' Disease

• Jung SH
• Song MY
• Shu BK
• Lee BC

Abstract

PURPOSE
Neopterin is a marker of activation of the T-lymphocyte/monocyte axis. We measured serum neopterin concentration to investigate whether serum neopterin levels are increased in children with Graves' disease and whether serum neopterin measurement can be used as a marker of disease activity in Graves disease.
METHODS
Twenty children with Graves' disease(3 boys and 17 girls) and 15 healthy children(7 boys and 8 girls) are enrolled in this study. Serum neopterin concentrations are measured by radioimmunoassay.
RESULTS
Neopterin concentration in children with Graves' disease(1.59+/-1.25ng/ml) is not higher than that of healthy children(1.51+/-0.73ng/ml). Neopterin concentration is not influenced by thyroid function and remission state.
CONCLUSION
Serum neopterin level in children with Graves' disease can not be used as a marker of activity.

Keyword

Graves disease; Neopterin

MeSH Terms

Axis, Cervical Vertebra
Child*
Graves Disease*
Humans
Neopterin*
Radioimmunoassay
Thyroid Gland
Neopterin