J Korean Soc Coloproctol.
2011 Jun;27(3):157-161. 10.3393/jksc.2011.27.3.157.
Concurrent Large Cell Neuroendocrine Carcinoma and Adenocarcinoma of the Ascending Colon: A Case Report
- Affiliations
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- 1Department of Pathology, Research Institute for Endocrine Science, Research Institute of Clinical Medicine, Chonbuk National University Medical School, Jeonju, Korea. hspark@chonbuk.ac.kr
- 2Department of Forensic Medicine, Research Institute for Endocrine Science, Research Institute of Clinical Medicine, Chonbuk National University Medical School, Jeonju, Korea.
- 3Department of Surgery, Research Institute for Endocrine Science, Research Institute of Clinical Medicine, Chonbuk National University Medical School, Jeonju, Korea.
- 4Department of Forensic Medicine, National Institute of Science Investigation, Seoul, Korea.
- KMID: 2198765
- DOI: http://doi.org/10.3393/jksc.2011.27.3.157
Abstract
- Large cell neuroendocrine carcinomas of the colon are rare and represent only a small percentage of all colonic endocrine tumors. Here, we report a case of a colonic large cell neuroendocrine carcinomas concurrent with a colonic adenocarcinoma. A 70-year-old man presented with acute abdominal pain. A spiral computed tomography scan of the abdomen revealed eccentric wall thickening on the ascending colon. An explorative laparotomy and a right hemicolectomy were performed. Grossly, two separated masses were observed in the proximal ascending colon. One was a 7.4 x 5.1 cm ulcerative fungating lesion, and the other was a 2.8 x 1.9 cm polypoid lesion. Microscopically, the ulcerative fungating lesion showed a well-differentiated neuroendocrine morphology with necrosis and increased mitosis. Most of the tumor cells had large, vesicular nuclei with eosinophilic nucleoli, variable amounts of eosinophilic cytoplasm, and immunoreactivity for chromogranin A and synaptophysin. The polypoid lesion was a well-differentiated adenocarcinoma that had invaded the submucosa. We diagnosed these lesions as a concurrent large cell neuroendocrine carcinoma and an adenocarcinoma of the ascending colon.
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