Korean J Gastroenterol.  2009 Jul;54(1):46-49. 10.4166/kjg.2009.54.1.46.

A Case of Large Cell Neuroendocrine Carcinoma of the Colon

• Kim HG
• Lee JI
• Jeong S
• Lee JW
• Kwon KS
• Kim HG
• Shin YW
• Kim L

• KMID: 1792766
• DOI: http://doi.org/10.4166/kjg.2009.54.1.46

Abstract

Neuroendocrine carcinoma of the colon can be classified into small cell carcinoma and large cell neuroendocrine carcinoma. The incidence of neuroendocrine carcinoma is so low that the guideline for the treatment of large cell neuroendocrine carcinoma of the colon are not established. The prognosis of large cell neuroendocrine carcinoma of the colon is worse than that of conventional adenocarcinoma of the colon. We report a case of large cell neuroendocrine carcinoma of the colon that treated with right hemicolectomy and 6th sequential combination chemotherapy of 5-fluorouracil and cisplatin. There has been no evidence of the recurrence or metastasis of tumor for 6 months.

Keyword

Colon cancer; Neuroendocrine carcinoma, Large cell

MeSH Terms

Adult
Carcinoma, Large Cell/*diagnosis/pathology/radiography
Carcinoma, Neuroendocrine/*diagnosis/pathology/radiography
Colonic Neoplasms/*diagnosis/pathology/radiography
Colonoscopy
Humans
Male
Tomography, X-Ray Computed

Figure

• 

  Fig. 1. Colonoscopic finding showed the ulceroinfiltrative mass with luminal narrowing at hepatic flexure.

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  Fig. 2. Enhanced abdominal CT scan showed a huge necrotic mass located in distal ascending colon with multiple regional lymphadenopathy around mesentery and small amount of ascites.

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  Fig. 3. Microscopic finding and immunohistochemical stain. Tumor cells featuring abundunt cytoplasm, prominent nucleoli, frequent mi-totic rate showed the organoid, nesting, trabecular and palisadng pattern (H&E, ×200) (A) and positive immunohistochemical stain for synaptophysin (Synaptophysin, ×200) (B).

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  Fig. 4. A huge ulcerofungating mass measuring 10.8×10.5×5.9 cm was located in ascending colon. Tumor cells invaded the per-icolic adipose tissue.

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