Intest Res.  2013 Apr;11(2):137-141. 10.5217/ir.2013.11.2.137.

Simultaneous Neuroendocrine Carcinoma and Adenocarcinoma of the Colon

• Shin D
• Park Y
• Gong S
• Kim S
• Jo Y
• Ahn S
• Han J
• Kim E

• KMID: 2174284
• DOI: http://doi.org/10.5217/ir.2013.11.2.137

Abstract

Neuroendocrine carcinoma of colon is a rare disease entity that is histologically poorly differentiated and immunochemically synaptophysin positive, enabling it to be confirmed by an immunohistochemical stain. Neuroendocrine carcinomas, in almost all cases, have poor prognosis due to a tendency of early metastasis and lack of standardized treatment. The concurrent diagnosis of neuroendocrine carcinoma and adenocarcinoma is extremely rare. The relation of these two disease entities is not understood. We experienced a patient with a colonic neuroendocrine carcinoma concurrent with adenocarcinoma. A 65-year-old male presented with abdominal pain. Emergent computed tomography suggested a malignant tumor of the ascending colon. Colonoscopy showed an infiltrative lesion in the ascending colon with a luminal narrowing, a large pedunculated lesion at the splenic flexure, and multiple small polyps in the descending colon. The patient underwent a right hemicolectomy including the pedunculated lesion. The pathology confirmed advanced neuroendocrine carcinoma in the ascending colon, adenocarcinoma in proximal descending colon, and multiple metastatic lymph nodes of neuroendocrine carcinomas on abdomen. The patient underwent the postoperative chemotherapy but did not tolerate it well and expired a year after diagnosis. We report this rare case with a review of the literature.

Keyword

Colonic Neoplasms; Carcinoma; Neuroendocrine; Adenocarcinoma

MeSH Terms

Abdomen
Abdominal Pain
Adenocarcinoma
Carcinoma, Neuroendocrine
Colon
Colon, Ascending
Colon, Descending
Colon, Transverse
Colonic Neoplasms
Colonoscopy
Humans
Lymph Nodes
Male
Neoplasm Metastasis
Phenobarbital
Polyps
Prognosis
Rare Diseases
Synaptophysin
Phenobarbital
Synaptophysin