J Korean Soc Ther Radiol.  1992 Dec;10(2):187-192.

Complication of Intraoperative Radiation Therapy (IORT) in Gastric Cancer

• Kim MS
• Kim SK
• Song SK
• Kim HJ
• Kwan KB
• Kim HD

Abstract

Local control is the important prognostic factor in cancer treatment because local control decrease the relative risk of metastatic spread and increse distant metastasis free survival. IORT is the modality which could increase local control without incressing complication, combined with curative operation. Eventhough we could achieve significant deacreased local failure by IORT and curative resection, it should not be committed as a main treatment modality without proving acceptable complications. Therapeutic Radiology Department of Yeungnam University Medical Center have tried 58 IORT from June 15, 1988, and performed 53 IORT in patients with gastric cancer. No local failure has been reporte? by regular follow up so far. Nine cases(17%) of treatment related complifaiton were reported including intestinal obstrution, hemorrhage, sepsis, and bone marrow depression. These complications could be comparable to Jo's 25.2% (chemotherapy + operation), Kim's 18% (chemotherapy only in inoperable patients), because our treatment regimen is consisted of IORT (1500 cGy), external irradiation(--4500 cGy) and extensive chemotherapy (FAM, 5FU+MMC, BACOP). Our data encouraged us to re-inforce further IORT in stomach cancer treatment.

Keyword

IORT; Gastric Cancer; Complication; External irradiation; Chemotherapy

MeSH Terms

Academic Medical Centers
Bone Marrow
Depression
Drug Therapy
Follow-Up Studies
Hemorrhage
Humans
Neoplasm Metastasis
Radiation Oncology
Sepsis
Stomach Neoplasms*