J Korean Med Sci.  1995 Dec;10(6):449-452. 10.3346/jkms.1995.10.6.449.

Preliminary experiences with intraoperative radiation therapy (IORT) for the treatment of brain tumors

• Chung YG
• Kim CY
• Lee HK
• Lee KC
• Chu JW
• Choi MS

• KMID: 927178
• DOI: http://doi.org/10.3346/jkms.1995.10.6.449

Abstract

Ten brain tumor patients underwent wide resection of the tumor followed by Intraoperative Radiation Therapy (IORT) at the first surgery or at the second salvage surgery after failure of conventional external beam irradiation. Two patients(1 meningioma, 1 glioblastoma multiforme) were treated at the first surgery and 8 patients(3 anaplastic astrocytoma, 3 glioblastoma multiforme, 1 meningioma, 1 gliosarcoma) were treated after salvage surgery. The IORT doses were ranged from 15-25 Gy depending on the tumor volume and previous radiation therapy. The neurological status(Karnofsky performance status) was improved in 4 cases, not changed in 6 cases after IORT. There were several complications after IORT; radiation necrosis, communicating hydrocephalus, wound infection, and abnormal CT findings such as diffuse low density area in an around operation site. The radiation necrosis was confirmed by operation in a recurrent meningioma patient 12 months after IORT. At follow-up, ranging from 1 to 16 months, there was no deaths. Based on our limited experiences, the IORT might be one of the adjuvant therapeutic modalities especially for the malignant brain tumors and unresectable huge meningioma.

Keyword

Glioblastoma multiforme; Anaplastic astrocytomas; Meningioma; IORT

MeSH Terms

Adult
Astrocytoma/radiotherapy/surgery
Brain Neoplasms/pathology/*radiotherapy/*surgery
Combined Modality Therapy
Female
Glioblastoma/radiotherapy/surgery
Gliosarcoma/radiotherapy/surgery
Human
Intraoperative Care
Male
Meningioma/radiotherapy/surgery
Middle Age
Salvage Therapy