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Prognostic Prediction Based on Dynamic Contrast-Enhanced MRI and Dynamic Susceptibility Contrast-Enhanced MRI Parameters from Non-Enhancing, T2-High-Signal-Intensity Lesions in Patients with Glioblastoma

Jo SW, Choi SH, Lee EJ, Yoo RE, Kang KM, Yun TJ, Kim JH, Sohn CH

Objective: Few attempts have been made to investigate the prognostic value of dynamic contrast-enhanced (DCE) MRI or dynamic susceptibility contrast (DSC) MRI of non-enhancing, T2-high-signal-intensity (T2-HSI) lesions of glioblastoma multiforme...
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Prognostic role of ALK-1 and h-TERT expression in glioblastoma multiforme: correlation with ALK gene alterations

Elsers D, Temerik DF, Attia AM, Hadia A, Hussien MT

Background: Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that is expressed in the developing central and peripheral nervous systems during embryogenesis. Human telomerase reverse transcriptase (h-TERT) protein resumption...
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Human Cytomegalovirus (HCMV)-infected Astrocytoma Cells Impair the Function of HCMV-specific Cytotoxic T Cells

Kim J, Lee WW, Hwang ES

Background: Human cytomegalovirus (HCMV) infection in glioblastoma multiforme (GBM) is associated with a poor prognosis and may affect the pathogenesis of GBM. In this study, we investigated the role of...
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Prognostic Value of Dynamic Contrast-Enhanced MRI-Derived Pharmacokinetic Variables in Glioblastoma Patients: Analysis of Contrast-Enhancing Lesions and Non-Enhancing T2 High-Signal Intensity Lesions

Kang Y, Hong EK, Rhim JH, Yoo RE, Kang KM, Yun TJ, Kim JH, Sohn CH, Park SW, Choi SH

Objective: To evaluate pharmacokinetic variables from contrast-enhancing lesions (CELs) and non-enhancing T2 high signal intensity lesions (NE-T2HSILs) on dynamic contrast-enhanced (DCE) magnetic resonance (MR) imaging for predicting progression-free survival (PFS)...
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Spinobulbar Muscular Atrophy Combined with Glioblastoma Multiforme

Oh HJ, Hong SA, Oh HJ, Seok JM

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Automatic disease stage classification of glioblastoma multiforme histopathological images using deep convolutional neural network

Yonekura A, Kawanaka H, Surya Prasath VB, Aronow BJ, Takase H

In the field of computational histopathology, computer-assisted diagnosis systems are important in obtaining patient-specific diagnosis for various diseases and help precision medicine. Therefore, many studies on automatic analysis methods for...
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Quality of Radiomic Features in Glioblastoma Multiforme: Impact of Semi-Automated Tumor Segmentation Software

Lee M, Woo B, Kuo MD, Jamshidi N, Kim JH

OBJECTIVE: The purpose of this study was to evaluate the reliability and quality of radiomic features in glioblastoma multiforme (GBM) derived from tumor volumes obtained with semi-automated tumor segmentation software. MATERIALS...
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Primary Glioblastoma of the Cerebellopontine Angle: Case Report and Review of the Literature

Lee JH, Kim JH, Kwon TH

Glioblastoma multiforme (GBM) is located most frequently in the cerebral hemispheres. Glioblastoma presenting as an extraaxial mass of cerebellopontine angle (CPA) is very rare in adults. We report a rare...
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Fourth Ventricular Lesions in Metastatic Gliomas: A Rare Predilection?

Khan MN, Poulin A, Essig M

Over the course of five years, a total of ten cases were collected of glioma patients in whom a distant lesion at the fourth ventricle was noted. A ‘distant lesion’...
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Primary Pontine Glioblastoma Multiforme: A Case Report and Review of the Literature

Baik J, Baek HJ, Moon JI, Cho SB, Choi BH, Bae K, Jeon KN, Choi DS, Shin HS

Glioblastoma multiforme (GBM) most commonly occurs in the pons while it is rare in the brainstem. However, diagnosis of brainstem GBM can be difficult due to its rarity and nonspecific...
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Glioblastoma specific antigens, GD2 and CD90, are not involved in cancer stemness

Woo SR, Oh YT, An JY, Kang BG, Nam DH, Joo KM

Glioblastoma multiforme (GBM) is the most malignant World Health Organization grade IV brain tumor. GBM patients have a poor prognosis because of its resistance to standard therapies, such as chemotherapy...
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Glioblastoma Multiforme in the Pineal Region with Leptomeningeal Dissemination and Lumbar Metastasis

Matsuda R, Hironaka Y, Suigimoto , Nakase H

We report a case of a 31-year-old woman with glioblastoma multiforme (GBM) in the pineal region with associated leptomeningeal dissemination and lumbar metastasis. The patient presented with severe headache and...
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Extraneural Metastases of Glioblastoma without Simultaneous Central Nervous System Recurrence

Kim W, Yoo H, Shin SH, Gwak HS, Lee SH

Glioblastoma multiforme (GBM) is well known as the most common malignant primary brain tumor. It could easily spread into the adjacent or distant brain tissue by infiltration, direct extension and...
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True Progression versus Pseudoprogression in the Treatment of Glioblastomas: A Comparison Study of Normalized Cerebral Blood Volume and Apparent Diffusion Coefficient by Histogram Analysis

Song YS, Choi SH, Park CK, Yi KS, Lee WJ, Yun TJ, Kim TM, Lee SH, Kim JH, Sohn CH, Park SH, Kim IH, Jahng GH, Chang KH

OBJECTIVE: The purpose of this study was to differentiate true progression from pseudoprogression of glioblastomas treated with concurrent chemoradiotherapy (CCRT) with temozolomide (TMZ) by using histogram analysis of apparent diffusion...
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Current Trends in Glioblastoma Multiforme Treatment: Radiation Therapy and Immune Checkpoint Inhibitors

Nicholas S, Mathios D, Ruzevick J, Jackson C, Yang I, Lim M

Glioblastoma multiforme (GBM) is the most common primary brain cancer. Even with aggressive combination therapy, the median life expectancy for patients with GBM remains approximately 14 months. In order to...
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Caring for Dying Patient with Glioblastoma Multiforme: A Narrative Analysis of the Caring Experience of Family Caregiver

Kim MA, Ryu E, Hong YP

PURPOSE: The purpose of this narrative study was to understand how family caregivers interpreted themselves life during caring for dying patients with gliobalstoma, and how they integrated these experiences into...
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Extraneural Metastasis of Glioblastoma Multiforme Presenting as an Unusual Neck Mass

Seo YJ, Cho WH, Kang DW, Cha SH

Glioblastoma multiforme (GBM) is the most aggressive intracranial tumor and it commonly spreads by direct extension and infiltration into the adjacent brain tissue and along the white matter tract. The...
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Glioblastoma Multiforme with Subcutaneous Metastases, Case Report and Literature Review

Guo L, Qiu Y, Ge J, Zhou D

Glioblastoma multiforme (GBM) is the most common primary brain tumor and the most malignant astrocytoma in adults, with rare extra-cranial metastases, especially for subcutaneous metastases. It could be easily misdiagnosed...
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Radiation-Induced Glioblastoma Multiforme in a Remitted Acute Lymphocytic Leukemia Patient

Joh D, Park BJ, Lim YJ

Radiation therapy has been widely applied for cancer treatment. Childhood acute lymphocytic leukemia (ALL), characterized by frequent central nervous system involvement, is a well documented disease for the effect of...
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Brain Tumor Stem Cells as Therapeutic Targets in Models of Glioma

Laks DR, Visnyei K, Kornblum H

At this time, brain tumor stem cells remain a controversial hypothesis while malignant brain tumors continue to present a dire prognosis of severe morbidity and mortality. Yet, brain tumor stem...
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