J Korean Neurosurg Soc.  1999 Sep;28(9):1305-1311.

Intraoperative Radiation Therapy(IORT) for the Treatment of Brain Tumors

• Chung YG
• Kim CY
• Choi MS
• Lee KC
• Lee HK

Abstract

Intraoperative Radiation Therapy(IORT) delivers a high single dose of radiation to a localized volume encompassing the tumor tissue as well as a minimal amount to the surrounding brain. The aims of the study are to evaluate the feasibility of IORT for the treatment of brain tumors, its effect on survival, and possible complications. Nineteen brain tumor patients underwent wide resection of the tumor followed by IORT at the first surgery or at the second salvage surgery. IORT was given for primary tumors in two patients, but was used for treating recurrent tumors in the other 17 patients. IORT doses of 15-25Gy was delivered depending on the tumor volume and previous radiation therapy. The mean follow-up after IORT was 11.5 months(range: 1-40 months). There were several complications after IORT; 1 radiation necrosis, 1 hydrocephalus,and 3 wound infections. For Glioblastomas cases, the median survival time after initial diagnosis was 14 months(SD, 6.4mo; range 10-28mo). An Unresectable huge highly vascularized meningioma was removed successfully after IORT. Based on our limited experiences, IORT may be considered as an adjuvant therapeutic modality, especially for malignant brain tumors and large rich vascularized meningioma.

Keyword

IORT; Brain tumors; Complications

MeSH Terms

Brain Neoplasms*
Brain*
Diagnosis
Follow-Up Studies
Glioblastoma
Humans
Meningioma
Necrosis
Tumor Burden
Wound Infection