J Korean Soc Emerg Med.  1999 Jun;10(2):165-174.

Effect of Pentoxifylline on Ischemia-Reperfusion Injury of Brain Following Cardiac Arrest in Rats

• Jeong SK
• Park KN
• Park SH
• Oh DR
• Lee WJ
• Rue EY
• Choi KH
• Kim YM
• Lee WJ
• Kim SK

Abstract

BACKGROUND: Two major events occurring in the cerebral hemodynamics after successful resuscitation from cardiac arrest are reactive hyperemia and postischemic hypoperfusion. In this study, we examined the effect of Pentoxifylline(PTX) on the rat brain following cardiac arrest.
METHODS
Fourteen rats were anesthetized and artificially ventilated. Cardiac angst was produced by chest compression and clamping of tracheal tube far 3 minutes in ketamine anesthetized rats. Circulation was restored by standard cardiopulmonary resuscitation methods. In 7 rats, PTX 10mg/kg was infused at 10min after cardiac angst(PTX group). In the other 7 rats, same amount of normal saline was infused(control group).
RESULTS
In both groups, hemodynamic variables, neurologic deficit(ND) score and histopathologic findings of hippocampal CA1 neurons were observed. Hemodynamic variables and ND score were not significandy different between two groups. Delayed ischemic neurons of hippocampal CA1 were decreased in PTX group(2.2+/-2.4%) compared with control group(9.1+/-1.2%).
CONCLUSIONS
: We conclude that PTX prevented development of delayed ischemic neurons in hippocampal CA1 after cardiac arrest. PTX may be useful in emergency situations following cardiac arrest.

MeSH Terms

Animals
Brain*
Cardiopulmonary Resuscitation
Constriction
Emergencies
Heart Arrest*
Hemodynamics
Hyperemia
Ketamine
Neurons
Pentoxifylline*
Rats*
Reperfusion Injury*
Resuscitation
Thorax
Ketamine
Pentoxifylline