J Korean Soc Emerg Med.  2009 Feb;20(1):72-79.

The Serial Changes of the Serum Interleukin-6 and Interleukin-10 Concentrations in Patients who Received Therapeutic Hypothermia after Successful Cardiopulmonary Resuscitation

• Jeong GY
• Lim YS
• Kim JJ
• Kim JK
• Kim CK
• Yang HJ
• Lee HS
• Lee MJ

Abstract

PURPOSE
We wanted to investigate the serial changes of the serum interleukin-6 (IL-6) and interleukin-10 (IL-10) concentrations, according to the neurological outcome, in patients who received therapeutic hypothermia after successful cardiopulmonary resuscitation. We also wanted to evaluate the usefulness of serum IL-6 and IL-10 as biochemical markers to predict the neurological outcome.
METHODS
We prospectively evaluated 23 patients who received therapeutic hypothermia after successful cardiopulmonary resuscitation. Blood samples were taken at 0, 4, 12, 24 and 48 hours after the return of spontaneous circulation. We compared the IL-6 and IL-10 levels between the good (CPC 1 to 2) and poor (CPC 3 to 5) neurological outcome (NO) groups.
RESULTS
The serum IL-6 level at 0 hr was significantly higher in the good NO group than that in the poor NO group. The periods of time that showed the greatest pattern of change between the good and poor NO groups were 4-12 hr for the IL-6 level and 0-4 hr for the IL-10 level. On the analysis of the ROC curve, the cut-off value for delta IL-10 (0-4 hr) was -5.4 pg/ml (AUC=0.827, sensitivity 80.0%, specificity 93.3%, p=0.032) and the cut-off value for delta IL-6 (4-12 hr) was 62.8 ng/ml (AUC=0.527, sensitivity 80.0%, specificity 34.0%, p=0.861, respectively).
CONCLUSION
Our study suggests that the early delta IL-10 can be used as a neurological prognostic marker for patients who are undergoing therapeutic hypothermia after successful cardiopulmonary resuscitation.

Keyword

Interleukin-6; Interleukin-10; Cardiac arrest; Hypothermia

MeSH Terms

Biomarkers
Cardiopulmonary Resuscitation
Heart Arrest
Humans
Hypothermia
Interleukin-10
Interleukin-6
Prospective Studies
ROC Curve
Sensitivity and Specificity
Interleukin-10
Interleukin-6