J Korean Soc Clin Toxicol.  2014 Dec;12(2):97-101.

A Case of Successful Resuscitation of 10,150 J Shocks and Therapeutic Hypothermia on Aconitine-induced Cardiovascular Collapse

• Moon HJ
• Lee JW
• Kim KH
• Jeong DK
• Kim JH
• Kim YK
• Lee HJ

Abstract

Aconitine, found in the Aconitum species, is highly extremely toxic, and has been known to cause fatal cardiac arrhythmias and cardiovascular collapse. Although several reports have described treatment of aconitine intoxication, management strategy for the patient in a hemodynamically compromised state who experienced cardiopulmonary collapse is unknown. We report here on a case of a successful cardiopulmonary resuscitation and therapeutic hypothermia in an aconitine-induced cardiovascular collapsed patient. A 73-year-old male who presented with nausea, vomiting, chest discomfort, and drowsy mental state after eating an herbal decoction made from aconite roots was admitted to the emergency department. He showed hemodynamic compromise with monomorphic ventricular tachycardia resistant to amiodarone and lidocaine. After 3 minutes on admission, he collapsed, and cardiopulmonary resuscitation was initiated. We treated him with repeated cardioversion/defibrillation of 51 times, 10,150 joules and cardiopulmonary resuscitation of 12 times, 69 minutes for 14 hours and therapeutic hypothermia for 36 hours. He recovered fully in 7 days.

Keyword

Aconitine; Induced hypothermia; Arrhythmias

MeSH Terms

Aconitine
Aconitum
Aged
Amiodarone
Arrhythmias, Cardiac
Cardiopulmonary Resuscitation
Eating
Emergency Service, Hospital
Hemodynamics
Humans
Hypothermia*
Hypothermia, Induced
Lidocaine
Male
Nausea
Resuscitation*
Shock*
Tachycardia, Ventricular
Thorax
Vomiting
Aconitine
Amiodarone
Lidocaine