J Korean Soc Emerg Med.  1998 Dec;9(4):571-577.

Patterns of Serum Interleukin-6 Concentration after Initial Successful Cardiopulmonary Resuscitation

• Park KN
• Park SH
• Hwang DY
• Kim HG
• Lee H
• Choi KH
• Lee WJ
• Jung US
• Kim HJ
• Kim SK

Abstract

OBJECTIVE
To investigate patterns of serial serum interleukin-6(IL-6) concentrations after initial successful cardiopulmonary resuscitation, and to access differences in serum IL16 concentrations in patients with Cerebral Performance Category(CPC, 1-2) and CPC(3-5) at the 5th day after cardiacpulmonary resuscitation(CPR).
METHODS
We studied prospectively 12 patients with spontaneous circulation after cardiopulmonary resuscitation. Venous blood samples were taken 2,4,12,24,48 and 72 hours after restoration of spontaneous circulation to measure serum IL-6 levels by the enzyme-linked immunosorbent assay.
RESULTS
Serum IL-6 concentrations in the severe neurologically disabled group(CPC, 3-5) were significantly increased at 2, 24 and 48 hours after restoration of spontaneous circulation compared with the less neurolgically disabled group. Also, serum IL-6 concentrations in the severe neurologic disabled group showed dual peak at 4 and 24 hours.
CONCLUSION
Our study demonstrates significant incense of seam IL-6 in patients with CPC(3-5) after successful cardiopulmonary resuscitation and the significant correlation between early increase of serum IL-6 and poor neurologic outcome. It suggests that early increase of serum IL-6 can be used as a prognostic marker after successful cardiopulmonary resuscitation.

MeSH Terms

Cardiopulmonary Resuscitation*
Enzyme-Linked Immunosorbent Assay
Humans
Interleukin-16
Interleukin-6*
Prospective Studies
Interleukin-16
Interleukin-6