J Korean Neurosurg Soc.  1989 Dec;18(7-12):977-984.

Flow Cytometric Analysis of T-cell Subsets in Brain Tumor Patients

• Nam J
• Kim HI
• Lee JC
• Park RK
• Chung HT

Abstract

The immunocompetence is important not only to kill the neoplastic cells but also to keep the neoplastic cells from growing further. T lymphocyte is plays the most important role in maintaining the tumor immunity efficiently. T lymphocyte has its specific functions depending in the subset of T lymphocytes. The author analyzed the T lymphocyte subsets in 31 brain tumor patients using anti-CD3, anti-CD4, anti-CD8 monoclonal antibodies and flow cytometry to determine the immunological status of brain tumor patients. All CD3, CD4 and CD8 subsets were reduced in both benign and malignant brain tumor patients but more signigicantly reduced in malignant tumor group. But in benign tumor group, the subtypes of T lymphocytes were not so different from those of normal healthy controls except the pituitary tumor patients, who showed the significant decrease in all the subtypes. In malignant tumor group, each subtype was signigicantly reduced and CD8 subtypes was markedly reduced in metastatic tumor patients, These analyses were considered to have the possibility to be contributable to planning the further immunotherapy and also the possibility to moniter the brain tumor patients clinically.

Keyword

Brain tumor; Immunocompetence; T-cell; Flow cytometry

MeSH Terms

Antibodies, Monoclonal
Brain Neoplasms*
Brain*
Flow Cytometry
Humans
Immunocompetence
Immunotherapy
Lymphocytes
Pituitary Neoplasms
T-Lymphocyte Subsets*
T-Lymphocytes*
Antibodies, Monoclonal