J Korean Neurol Assoc.  1989 Jun;7(1):19-25.

The Therapeutic Effect of Drug in Parkinson's Disease

• Choi IS
• Lee MS
• Lee YJ
• Chung WY
• Lee SS
• Kim WT

Abstract

Two hundred and four patients with Parkinson's disease initially treated wth a combination of levodopa and carbidopa ( Sinement 25-250 ) and / or anticholinergic drugs. All patients responded initially to drug. Sixteen patients(7.8%) had 20 acute central nervous system side effects: 8, dyskinesia: 6, visual hallucination:5, psychosis: and 1, akathisia. The response to treatment usually was stable for the first one and a half to four years of drug therapy. Subsequently, over 50 percent of patients had therapeutic failure among 82 patients with long term drug therapy, fourteen(l7.0%) had 18 side effects: 8, on-off phenomenon: 4. Morning dystonia: 3, dyskinesia:and 3, simultaneous dyskinesia with parkinsonism. None had diphasic dyskinesia or myoclonus. The prognosis of the demented parkinsonian was relatively poor. Two patients died due to pneumonia and ovarian carcinoma.

MeSH Terms

Carbidopa
Central Nervous System
Drug Therapy
Dyskinesias
Dystonia
Humans
Levodopa
Myoclonus
Parkinson Disease*
Parkinsonian Disorders
Pneumonia
Prognosis
Psychomotor Agitation
Psychotic Disorders
Carbidopa
Levodopa