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Intrafamilial variability and clinical heterogeneity in a family with PLA2G6-associated neurodegeneration

Park JK, Youn J, Cho JW

Phospholipase A2 group VI (PLA2G6)-associated neurodegeneration (PLAN) is an autosomal recessive neurodegenerative disease with a wide clinical spectrum; however, the genotype-phenotype correlation is unknown. Here, we report different phenotypes in...
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Pharmacological Treatment in Parkinson's Disease

Lee JJ

Parkinson's disease is one of the most common neurodegenerative disorders world widely. Although curable therapies are practically not available yet, symptomatic managements using anti-Parkinson medications have shown to be quite...
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Less Pulsatile Levodopa Therapy (6 Doses Daily) Is Associated with a Reduced Incidence of Dyskinesia

Lin MM, Laureno R

OBJECTIVE: To evaluate whether less pulsatile levodopa therapy (LPT) can reduce the development of levodopa-induced dyskinesia (LID). METHODS: This is a retrospective cohort study of patients with Parkinson’s disease at the...
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A Patient with Myotonic Dystrophy Type 1 Presenting as Parkinsonism

Choi JH, Lee JY, Kim HJ, Jeon B

The current body of literature contains 5 reports of myotonic dystrophy (DM) with parkinsonism: 4 reports of DM type 2 and 1 report of clinically suspected DM type 1. To...
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Ameliorative Effects of Ombuoside on Dopamine Biosynthesis in PC12 Cells

Davaasambuu U, Park KH, Park HJ, Choi HS, Lee CK, Hwang BY, Lee MK

This study investigated the effects of ombuoside, a flavonol glycoside, on dopamine biosynthesis in PC12 cells. Ombuoside at concentrations of 1, 5, and 10 µM increased intracellular dopamine levels at...
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Amantadine and the Risk of Dyskinesia in Patients with Early Parkinson's Disease: An Open-Label, Pragmatic Trial

Kim A, Kim YE, Yun JY, Kim HJ, Yang HJ, Lee WW, Shin CW, Park H, Jung YJ, Kim A, Kim Y, Jang M, Jeon B

OBJECTIVE: We examined whether amantadine can prevent the development of dyskinesia. METHODS: Patients with drug-naïve Parkinson's disease (PD), younger than 70 years of age and in the early stage of PD...
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A Case of Dopa-responsive Dystonia with a Mutation in the GCH1 Gene Misdiagnosed as Cerebral Palsy for 2 Years

Yi CH, Yang HJ, Kim HJ, Lee KY

Dopa-responsive dystonia (DRD) is characterized by lower limb-onset, diurnally fluctuating dystonia and dramatic and sustained response to levodopa treatment. Segawa disease, an autosomal dominant deficiency of guanosine triphosphate cyclohydrolase 1...
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Risk Factors for Cognitive Impairment in Patient with Parkinson's Disease Treated with Levodopa

Kim KS, Lee KE, Lee MK

BACKGROUND: Long-term levodopa therapy relieves the motor dysfunction associated with Parkinson's disease (PD), but has various effects on non-motor symptoms, including cognitive dysfunction, hallucinations, and affective disorders, and can exacerbate...
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Clinical Predictors of Excessive Daytime Sleepiness in Patients with Parkinson's Disease

Junho BT, Kummer A, Cardoso F, Teixeira A, Rocha NP

BACKGROUND AND PURPOSE: Excessive daytime sleepiness (EDS) is a common complaint among patients with Parkinson's disease (PD). Several factors have been associated with EDS in PD, especially neuropsychiatric symptoms. This...
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Consolidation of a Learned Skill Correlates with Dopamine SPECT Uptake in Early Parkinson's Disease

Nicastro N, Manuel AL, Garibotto , Burkhard P, Schnider A

BACKGROUND AND PURPOSE: Basal ganglia play a pivotal role in procedural memory. However, the correlation between skill learning and striatal 123I-ioflupane uptake in Parkinson's disease (PD) has not been reported...
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Liquid Levodopa/Carbidopa: Old Solution, Forgotten Complication

Vijiaratnam N, Cheng S, Bertram KL, Williams D

No abstract available.
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Sleepiness and Depression in Parkinson's Disease Patients Treated with Ropinirole and Levodopa

Kang SY, Ryu HS, Sunwoo MK, Kim SJ, Baik JS, Park MY, Park HE, Kim JS, Kwon KY, Koh SB, Kim YE, Lee MK, Kim JM, Chung SJ, Sohn YH

OBJECTIVE: We aimed to investigate the effect of ropinirole on excessive daytime sleepiness (EDS) and depression in Parkinson’s disease (PD) with a large population. METHODS: We conducted a cross-sectional observational study...
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Comparison of Pallidal and Subthalamic Deep Brain Stimulation in Parkinson's Disease: Therapeutic and Adverse Effects

Ryu HS, Kim MS, You S, Kim MJ, Kim YJ, Kim J, Kim K, Chung SJ

OBJECTIVE: To compare the therapeutic and adverse effects of globus pallidus interna (GPi) and subthalamic nucleus (STN) deep brain stimulation (DBS) for the treatment of advanced Parkinson's disease (PD). METHODS: We...
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Association of Helicobacter pylori with Parkinson's Disease

Mridula KR, Borgohain , Chandrasekhar Reddy V, Bandaru VC, Suryaprabha T

BACKGROUND AND PURPOSE: Parkinson's disease (PD) is a major neurological disorder that requires lifelong treatment, and the combined presence of Helicobacter pylori (H. pylori) infection can increase the required anti-PD...
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Effects of Gypenosides on Dopaminergic Neuronal Cell Death in 6-Hydroxydopamine-lesioned Rat Model of Parkinson's Disease with Long-term L-DOPA Treatment

Shin KS, Zhao TT, Park HJ, Kim KS, Choi HS, Lee MK

The goal of this study was to determine whether gypenosides (GPS) exert protective effects against dopaminergic neuronal cell death in a 6-hydroxydopamine (OHDA)-lesioned rat model of Parkinson's disease (PD) with...
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Palmitoyl Serotonin Inhibits L-dopa-induced Abnormal Involuntary Movements in the Mouse Parkinson Model

Park HY, Ryu YK, Go J, Son E, Kim KS, Kim MR

L-3,4-dihydroxyphenylalanine (L-DOPA) is the most common treatment for patients with Parkinson's disease (PD). However, long term use of L-DOPA for PD therapy lead to abnormal involuntary movements (AIMs) known as...
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Association between Parkinson's Disease and Helicobacter Pylori

Çamcı G, Oğuz S

Helicobacter pylori (HP) is a common infection of the gastrointestinal system that is usually related to peptic ulcers. However, recent studies have revealed relationships between HP and many other diseases....
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Nerve Conduction Study for Patients with Parkinson Disease Who Developed Persistent Sensory Symptom during Optimal Levodopa Treatment

Kang YJ, Ko JA, Lee TK, Park JH

OBJECTIVE: Sensory symptoms are common in patients with Parkinson disease (PD), although its exact prevalence and causes are not well known. We aimed to investigate whether peripheral pathology contribute to...
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Effect of Subthalamic Deep Brain Stimulation on Levodopa-Induced Dyskinesia in Parkinson's Disease

Kim JH, Chang WS, Jung HH, Chang JW

PURPOSE: To evaluate the effect of bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) on levodopa-induced peakdose dyskinesia in patients with Parkinson's disease (PD). MATERIALS AND METHODS: A retrospective review was...
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Phenolic Compounds from the Leaves of Stewartia pseudocamellia Maxim. and their Whitening Activities

Roh HJ, Noh HJ, Na CS, Kim CS, Kim KH, Hong CY, Lee KR

The half-dried leaves of Stewartia. pseudocamellia were extracted with hot water (SPE) and partitioned with n-hexane (SPEH), dichloromethane (SPED), and ethyl acetate (SPEE) successively. SPE and SPEE showed significant inhibitory...
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