J Korean Epilepsy Soc.
2008 Jun;12(1):52-54.
A Case of Epilepsy Exhibiting a Severe, Dose-Dependent, Memory Deficit after Zonisamide Administration
- Affiliations
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- 1Department of Neurology, School of Medicine, Kyungpook National University, Daegu, Korea. sppark@mail.knu.ac.kr
- 2Department of Pediatrics, School of Medicine, Kyungpook National University, Daegu, Korea.
Abstract
- Zonisamide (ZNS) has been proven as a safe, effective, and well-tolerated antiepileptic drug. We report an epilepsy patient who had a severe, dose-dependent, memory deficit after ZNS administration. A 65-year-old man visited our epilepsy clinic due to the occurrence of nocturnal convulsions. Despite the absence of seizures, he developed a severe impairment of verbal and visual memory functions after the increment of ZNS dosage from 200 mg/day to 300 mg/day. We substituted 1,000 mg/day valproic acid for ZNS. His cognitive performances were returned to original levels.
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