J Clin Neurol.  2014 Jul;10(3):272-275. 10.3988/jcn.2014.10.3.272.

Opsoclonus-Myoclonus Syndrome Associated with Mumps Virus Infection

• Kang BH
• Kim JI

• KMID: 2179457
• DOI: http://doi.org/10.3988/jcn.2014.10.3.272

Abstract

BACKGROUND
Opsoclonus-myoclonus syndrome (OMS) is a rare neurological disorder that is characterized by involuntary eye movements and myoclonus. OMS exhibits various etiologies, including paraneoplastic, parainfectious, toxic-metabolic, and idiopathic causes. The exact immunopathogenesis and pathophysiology of OMS are uncertain.
CASE REPORT
We report the case of a 19-year-old male who developed opsoclonus and myoclonus several days after a flu-like illness. Serological tests revealed acute mumps infection. The findings of cerebrospinal fluid examinations and brain magnetic resonance imaging were normal. During the early phase of the illness, he suffered from opsoclonus and myoclonus that was so severe as to cause acute renal failure due to rhabdomyolysis. After therapies including intravenous immunoglobulin, the patient gradually improved and had fully recovered 2 months later.
CONCLUSIONS
This is the first report of OMS associated with mumps infection in Korea. Mumps infection should be considered in patients with OMS.

Keyword

opsoclonus; myoclonus; mumps virus

MeSH Terms

Acute Kidney Injury
Brain
Cerebrospinal Fluid
Eye Movements
Humans
Immunoglobulins
Korea
Magnetic Resonance Imaging
Male
Mumps
Mumps virus*
Myoclonus
Nervous System Diseases
Ocular Motility Disorders
Opsoclonus-Myoclonus Syndrome*
Rhabdomyolysis
Serologic Tests
Young Adult
Immunoglobulins

Figure

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  Fig. 1 There is no abnormality on the brain MRIs.

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